A Novel Epidermal Growth Factor-Containing Wound Dressing for the Treatment of Hard-to-Heal Venous Leg Ulcers
A Novel Epidermal Growth Factor-Containing Wound Dressing for the Treatment of Hard-to-Heal Venous Leg Ulcers
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DOI：
10.1097/01.asw.0000451942.39446.c2
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发表时间：
2014-10-01
影响因子：
2.4
通讯作者：
Stuecker, Markus
中科院分区：
文献类型：
--
作者：
Doerler, Martin;Eming, Sabine;Stuecker, Markus
目的：为了评估一种新的伤口敷料的疗效，耐受性和安全性，含有表皮生长因子（EGF）的胶原凝胶基质上难以愈合的静脉腿ulcers.PATIENTS和方法：作者包括33难愈合的静脉腿溃疡31例。含EGF的敷料贴敷3次，同时继续进行最佳实践保守伤口治疗。在1、2和3个月后对患者进行随访，以评价（a）伤口大小，（B）敷料的易应用性和溶解性，以及（c）伤口敷料，评分范围为1 - 5（1 =最佳，5 =最差）。停药原因为伤口感染、疼痛和失访（各n = 2）。3个月后，平均伤口表面显著减少（从33.69 cm（2）减少到18.94 cm（2），P = 0.023）。在从0到100的量表上，伤口敷料被评价为非常容易涂抹和高度溶解（平均值分别为97.14和98.11; 100 =非常容易涂抹或100%溶解）。敷料一般耐受性良好，平均总评分为2.16的医疗保健专家和2.40 patients.CONCLUSION：作者的研究结果表明，新的含EGF的伤口敷料一般耐受性良好，安全。结合显著的伤口表面减少，它可以被视为难以愈合的下肢静脉溃疡患者的一种适当的新型治疗选择。
OBJECTIVE: To evaluate the efficacy, tolerability, and safety of a novel wound dressing containing epidermal growth factor (EGF) in a collagen-gel matrix on hard-to-heal venous leg ulcers.PATIENTS AND METHODS: The authors included 33 hard-to-heal venous leg ulcers found on 31 patients. The EGF-containing dressing was applied 3 times while best practice conservative wound treatment was continued. Patients were followed up with after 1, 2, and 3 months to evaluate (a) the wound size, (b) the ease of application and dissolution of the dressing, and (c) the wound dressing by means of a scale ranging from 1 to 5 (1 = best, 5 = worst).RESULTS: The protocol was completed by 25 of 31 patients. The reasons for discontinuation were wound infection, pain, and lost to follow-up (n = 2 each, respectively). After 3 months, the average wound surface was significantly reduced (from 33.69 cm(2) to 18.94 cm(2), P = .023). On a scale from 0 to 100, the wound dressing was evaluated as very easy to apply and highly dissolvable (mean value of 97.14 and 98.11, respectively; 100 = very easy to apply or 100% dissolution). The dressing was generally well tolerated and scored a mean overall rating of 2.16 by healthcare specialists and 2.40 by patients.CONCLUSION: The authors' results demonstrate that the novel EGF-containing wound dressing was generally well tolerated and safe. Combined with the significant wound surface reduction, it can be regarded as an adequate novel treatment option for patients with hard-to-heal venous leg ulcers.