Common genetic effects on variation in impulsivity and activity in mice
Common genetic effects on variation in impulsivity and activity in mice
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DOI：
10.1523/jneurosci.1650-04.2004
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发表时间：
2004-07-28
影响因子：
5.3
通讯作者：
Wilkinson, LS
中科院分区：
文献类型：
--
作者：
Isles, AR;Humby, T;Wilkinson, LS
冲动是一种复杂的心理结构，在正常范围内影响行为倾向，并已被证明具有遗传因素，通过检查异常条件的遗传模式，如注意力缺陷/多动障碍和强迫症。在这项研究中，我们利用近交系小鼠的等基因性质，通过检查四种不同小鼠品系在一种新型小鼠延迟强化范式中的表现来确定基因对冲动行为的贡献，在此期间，动物必须在相对较小但立即可用的奖励和较大但逐渐延迟的奖励之间进行选择。为了控制母体效应，所有小鼠在出生后立即交叉培养到共同品系。在这些条件下，我们发现显着差异的行为索引冲动的选择和独立的措施的自发活动，随后的遗传力分析表明，可能是相关的，部分，遗传效应的菌株。此外，这两个方面的行为被发现是共同变化的，更活跃的动物也表现出更多的冲动行为。这并不归因于与个人任务要求相关的世俗混乱，而是表明存在影响冲动和运动活动变化的常见遗传因素。这些数据进行了讨论的冲动和多动症的共存，环境和遗传效应之间的相互作用，和可能的候选基因。
Impulsivity is a complex psychological construct that impacts on behavioral predispositions in the normal range and has been shown to have a genetic element through the examination of hereditary patterns of abnormal conditions such as attention deficit/hyperactivity disorder and obsessive compulsive disorder. In this study, we took advantage of the isogenic nature of inbred strains of mice to determine the contribution of genes to impulsive behaviors by examining the performance of four separate mouse strains in a novel murine delayed-reinforcement paradigm, during which the animals had to choose between rewards that were relatively small but available immediately and larger but progressively delayed rewards. To control for maternal effects, all the mice were cross-fostered to a common strain immediately after birth. Under these conditions, we found significant differences between the strains on behaviors indexing impulsive choice and on independent measures of locomotor activity, which subsequent heritability analysis showed could be related, in part, to genetic effects. Moreover, the two aspects of behavior were found to co-vary, with the more active animals also displaying more impulsive behavior. This was not attributable to mundane confounds related to individual task requirements but instead indicated the existence of common genetic factors influencing variation in both impulsivity and locomotor activity. The data are discussed in terms of the coexistence of impulsivity and hyperactivity, interactions between environmental and genetic effects, and possible candidate genes.