Effects of exercise on the hemostatic system of Thoroughbred horses displaying post-exercise epistaxis.
Effects of exercise on the hemostatic system of Thoroughbred horses displaying post-exercise epistaxis.
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DOI：
10.1016/s0737-0806(83)80013-6
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发表时间：
1983-01-01
影响因子：
1.3
通讯作者：
Grant, B. D.
中科院分区：
文献类型：
--
作者：
Bayly, W. M.;Meyers, K. M.;Grant, B. D.
对5匹最近出现运动后鼻出血的纯种马和4匹正常马，在安静时、运动前即刻和以最大速度奔跑1.2公里后5分钟采集血样，测定了它们的止血值。运动可显著抑制二磷酸腺苷(ADP)诱导的两组马的血小板聚集反应。比较各组的结果，均未发现显著差异。然而，出血组的血小板对ADP的反应有降低的趋势。由于并未对血小板功能的所有方面进行研究，因此不能完全否定血小板异常在运动性肺出血发病机制中的可能作用。
Haemostatic values in 5 Thoroughbreds which had recently displayed post-exercise epistaxis, and 4 normal horses, were assessed using blood samples taken when the animals were at rest, immediately before exercise, and 5 minutes after galloping 1.2 km at maximum speed. Exercise resulted in marked depression in the adenosine diphosphate (ADP)-induced aggregation response of platelets from both groups of horses. No significant differences were detected when comparing the results from each group. However, there was a tendency for the platelets from the bleeder group to be less responsive to ADP. Because not all aspects of platelet function were studied, the possible role of platelet abnormalities in the pathogenesis of exercise-induced pulmonary haemorrhage could not be completely discounted.