Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
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DOI：
10.3389/fimmu.2017.01078
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发表时间：
2017
影响因子：
7.3
通讯作者：
Fric J
中科院分区：
文献类型：
--
作者：
Jose SS;Bendickova K;Kepak T;Krenova Z;Fric J
乳腺癌相关的免疫力下降的特征是干细胞耗竭、端粒缩短和细胞间通讯中断，导致患者患病风险增加。最近的数据表明，慢性炎症对免疫衰老产生强烈影响，并且在一系列主要病理中与端粒长度密切相关。目前的综述讨论了炎症对免疫衰老的影响，这一过程中可能的分子介质，以及与免疫衰老有关的各种疾病状态。新的发现涉及NF-κB，炎症信号的主要驱动因素，在调节端粒维持和/或端粒酶活性的几个过程。虽然现在已知模式识别受体的长时间触发会促进免疫衰老，但仍不清楚该过程如何与端粒复合物或端粒酶活性相关联。事实上，端粒长度的酶控制已经研究了几十年，但端粒酶的替代作用和对炎症反应的潜在影响现在才开始出现。这些途径之间的串扰可能被证明是免疫衰老的关键分子机制。了解免疫老化的组成部分如何相互作用并改变宿主对病原体和肿瘤的保护，对于设计适用于各种临床情况的新疫苗和疗法至关重要。
Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence. Emerging findings implicate NF-κB, the major driver of inflammatory signaling, in several processes that regulate telomere maintenance and/or telomerase activity. While prolonged triggering of pattern recognition receptors is now known to promote immunosenescence, it remains unclear how this process is linked with the telomere complex or telomerase activity. Indeed, enzymatic control of telomere length has been studied for many decades, but alternative roles of telomerase and potential influences on inflammatory responses are only now beginning to emerge. Crosstalk between these pathways may prove to be a key molecular mechanism of immunosenescence. Understanding how components of immune aging interact and modify host protection against pathogens and tumors will be essential for the design of new vaccines and therapies for a wide range of clinical scenarios.
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影响因子：
3.9
作者：
Al-Ajmi, Nouf;Saretzki, Gabriele;Spyridopoulos, Ioakim
通讯作者：
Spyridopoulos, Ioakim
影响因子：
11.4
作者：
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通讯作者：
Defrance, T.
影响因子：
5
作者：
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通讯作者：
Varga, John
影响因子：
3.2
作者：
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通讯作者：
Burnham, Ellen L.
DOI：
10.1152/ajpendo.00302.2006
发表时间：
2007-03-01
影响因子：
5.1
作者：
Creely, S. J.;McTernan, P. G.;Kumar, S.
通讯作者：
Kumar, S.