Studies on medicinal plants of Ivory Coast:: Investigation of Sida acuta for in vitro antiplasmodial activities and identification of an active constituent
Studies on medicinal plants of Ivory Coast:: Investigation of Sida acuta for in vitro antiplasmodial activities and identification of an active constituent
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DOI：
10.1078/0944711041495245
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发表时间：
2004-04-01
期刊：
影响因子：
7.9
通讯作者：
Blache, Y
中科院分区：
文献类型：
--
作者：
Banzouzi, JT;Prado, R;Blache, Y
黄花稔（锦葵科）起源于象牙海岸后，民族植物学调查选择：疟疾的传统治疗者通常使用这种植物的治疗。提取物在两种恶性疟原虫菌株上进行了测试：FcM 29-喀麦隆（氯喹抗性菌株）和尼日利亚氯喹敏感菌株。提取物是通过在水中制备植物粉末的汤剂获得的，这是大多数传统治疗师使用的技术。然后制备乙醇提取物并进行测试。这些提取物获得的IC 50值范围为3.9至-5.4 mug/ml。这种活性组分的纯化导致鉴定cryptolepine作为植物的活性抗疟原虫成分。
Sida acuta Burm. (Malvaceae) originating from Ivory Coast was selected after an ethnobotanical survey: traditional healers of malaria commonly used this plant for the treatment. Extracts were tested on two strains of Plasmodium falciparum: FcM29-Cameroon (chloroquine-resistant strain) and a Nigerian chloroquine-sensitive strain. Extracts were obtained by preparing decoction in water of the powdered plant, the technique used by most of the traditional healers. An ethanol extract was then made and tested. The IC50 values obtained for these extracts ranged from 3.9 to -5.4 mug/ml. Purification of this active fraction led to the identification of cryptolepine as the active antiplasmodial constituent of the plant.