Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy.
Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy.
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DOI：
10.1016/j.biomaterials.2014.05.045
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发表时间：
2014-08
期刊：
影响因子：
14
通讯作者：
Huang, Leaf
中科院分区：
文献类型：
--
作者：
Guo, Shutao;Wang, Yuhua;Miao, Lei;Xu, Zhenghong;Lin, Ching-Hsuan M.;Huang, Leaf
将水不溶性有机化合物配制成纳米颗粒已经成为广泛建立的用于增强癌症治疗剂的递送和功效的方法。因此，当应用于水不溶性无机化合物时，类似的方法也应该促进类似的优点。在此，我们已经成功地将不溶性碘化顺铂（CDDP-1）配制成LPI NP（脂质包覆的碘化CDDP纳米颗粒）。将两种单独的微乳液合并，每种微乳液含有用于合成CDDP-I的前体。然后用阴离子脂质包被所得CDDP-1沉淀物，并在另外的脂质的帮助下分散在水中。该方法使我们能够有效地包封CDDP-I，并且能够实现82wt%的相当大的载药量。施用的LPI NP在肿瘤组织中表现出高水平的蓄积，并且在两种黑素瘤异种移植模型中表现出与游离CDDP相当的抗癌活性，而不诱导肾毒性。通过该递送制剂提供的益处不是CDDP-1所独有的，因为该通用平台可以扩展到水和油均不溶于纳米颗粒的其他无机化合物的制剂，以获得上级抗癌功效。
The formulation of water insoluble organic compounds into nanoparticles has become a widely established method for enhancing the delivery and efficacy of cancer therapeutics. Therefore, a comparable approach when applied to water insoluble inorganic compounds should also promote similar advantages. Herein, we have successfully formulated insoluble iodinated cisplatin (CDDP-I) into a LPI NPs (lipid-coated iodinated CDDP nanoparticles). Two separate microemulsions were combined, each containing a precursor for the synthesis of CDDP-I. The resulting CDDP-I precipitate was then coated with an anionic lipid and dispersed in water with the help of an additional lipid. This method allows us to effectively encapsulate CDDP-I and was able to achieve a considerable drug loading of 82 wt%. Administered LPI NPs demonstrated high level accumulation in tumor tissues and exhibited an anti-cancer activity comparable to free CDDP in two melanoma xenograft models without inducing nephrotoxocity. The benefits offered through this delivery formulation are not unique to CDDP-I, as this versatile platform may be extended to the formulation of other inorganic compounds that are both water and oil insoluble into nanoparticles for superior anticancer efficacy.
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影响因子：
10.8
作者：
Fonseca, C;Simoes, S;Gaspar, R
通讯作者：
Gaspar, R
影响因子：
17.1
作者：
Guo, Shutao;Wang, Yuhua;Miao, Lei;Xu, Zhenghong;Lin, C. Michael;Zhang, Yuan;Huang, Leaf
通讯作者：
Huang, Leaf
影响因子：
82.9
作者：
Burger, KNJ;Staffhorst, RWHM;de Kruijff, B
通讯作者：
de Kruijff, B
DOI：
10.1073/pnas.0915085107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Kang, Tae-Hong;Lindsey-Boltz, Laura A.;Sancar, Aziz
通讯作者：
Sancar, Aziz
影响因子：
17.1
作者：
Aryal S;Hu CM;Zhang L
通讯作者：
Zhang L