ANTERIOR CERVICAL DISCECTOMY AND INTERBODY FUSION - EXPERIMENTAL-STUDY USING A SYNTHETIC TRICALCIUM PHOSPHATE
ANTERIOR CERVICAL DISCECTOMY AND INTERBODY FUSION - EXPERIMENTAL-STUDY USING A SYNTHETIC TRICALCIUM PHOSPHATE
复制标题
DOI：
10.3171/jns.1979.51.4.0533
复制
发表时间：
1979-01-01
影响因子：
4.1
通讯作者：
DUNSKER, SB
中科院分区：
文献类型：
--
作者：
SHIMA, T;KELLER, JT;DUNSKER, SB
观察磷酸三钙陶瓷植入颈椎间隙后的组织学、组织化学变化及成骨性。20只犬C3-C6颈椎暴露，在第3和第5间隙行椎间盘切除术。在第3位插入Synthos的销子，在第5位插入新鲜的肱骨自体移植物。实验动物分为5组，每组4只。术后3、6、12、18、22周各处死4只。C3-C6椎体整体切除。每个标本各取一半进行骨发育组织学检查；另一半则采用Suzuki和Matthews的二色荧光标记技术测定手术和牺牲时的成骨情况。注意到Synthos固定钉不同程度的压迫，70%的病例发生前位和/或后位假体移位。显然，Synthos植入物在生物化学和生物力学上是不可接受的。
The histological and histochemical changes and osteogenicity of Synthos (tricalcium phosphate ceramic) implanted in the cervical intervertebral space were evaluated. The cervical vertebrae from C3-C6 were exposed in 20 dogs and discectomy was performed at the 3rd and 5th spaces. A dowel of Synthos was inserted into the 3rd space, and a piece of fresh autologous graft from the humerus was inserted into the 5th place. The animals were divided into 5 groups with 4 animals in each. Four animals were sacrificed at each of 3, 6, 12, 18 and 22 wk after the procedure. The C3-C6 vertebrae were removed en bloc. One half of each specimen was processed for histological examination of bone development; the other half was processed for the 2 color fluorescent labeling technique of Suzuki and Matthews for determination of osteogenesis at the time of operation and sacrifice. Various degrees of compression of the Synthos dowel were noted, with anterior and/or posterior displacement of the implant in 70% of the cases. Apparently the Synthos implant was biochemically and biomechanically unacceptable for this investigation.