Methods to detect Helicobacter pylori:: From culture to molecular biology
Methods to detect Helicobacter pylori:: From culture to molecular biology
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DOI：
10.1111/j.1523-5378.2007.00560.x
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发表时间：
2007-11-01
期刊：
影响因子：
4.4
通讯作者：
Makristathis, Athanasios
中科院分区：
文献类型：
--
作者：
Hirschl, Alexander M.;Makristathis, Athanasios
自从第一次成功尝试生长幽门螺杆菌以来，已经描述了用于检测这种病原体感染的各种测试。这些测试可以分为侵入性和非侵入性或微创测试。传统的检查，如组织学和文化仍然发挥着重要作用，在诊断谱。培养仍然是唯一能够全面分析病原体特征和对抗生素敏感性的测试。尿素呼气试验是无创性检测中的金标准，在特定情况下，粪便抗原检测和血清学检测可作为适当的替代或替代方法。在分子检测的多种潜在用途中，对抗生素抗性的非侵入性测定特别令人感兴趣。
Since the first successful attempts of growing Helicobacter pylori, a variety of tests for detecting infection with this pathogen has been described. These tests may be classified as invasive and noninvasive or minimally invasive tests. Conventional tests such as histology and culture still play a major role in the diagnostic spectrum. Culture continues to be the only test allowing for a comprehensive analysis of pathogen characteristics and susceptibility to antibiotics. Urea breath test is the gold standard among noninvasive tests, with both stool antigen test and serology as appropriate substitutes or alternatives in specific situations. Among the multiple potential uses of molecular tests, noninvasive determination of resistance to antibiotics is of particular interest.