Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma.
Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma.
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DOI：
10.1007/s13277-015-4148-x
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Guo L
中科院分区：
文献类型：
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作者：
Zhu Q;Cao SM;Lin HX;Yang Q;Liu SL;Guo L
酰基甘油激酶（AGK）已被报道促进恶性表型和增强癌症干细胞的发展。然而，AGK在癌症中的临床价值仍不清楚。本研究旨在探讨AGK在鼻咽癌组织中的表达及其临床病理意义。实时荧光定量PCR和免疫印迹法检测结果显示，AGK在鼻咽癌细胞系和临床标本中表达显著上调。在AGK阳性病例中，52/114（45.6%）的存档人NPC标本表达高水平的AGK。AGK高表达与总生存期和无病生存期显著缩短相关（P < 0.001和P = 0.002;对数秩检验），是总生存期的独立预后因素（P = 0.041;多变量考克斯分析）。AGK高表达与淋巴结转移有关（P < 0.001;卡方检验），是NPC淋巴结转移的独立预测因素（P = 0.032;多因素Logistic分析）。AGK在鼻咽癌组织中的过度表达与疾病进展和淋巴结转移有关。AGK有可能作为一个新的预后因素的总生存在NPC。
Acylglycerol kinase (AGK) has been reported to promote a malignant phenotype and enhance the development of cancer stem cells. However, the clinical value of AGK in cancer remains unclear. This study aimed to investigate the expression and clinicopathological significance of AGK in nasopharyngeal carcinoma (NPC). AGK was significantly upregulated in NPC cell lines and clinical specimens as indicated by real-time PCR and Western blotting. Among the AGK-positive cases, 52/114 (45.6 %) of the archived human NPC specimens expressed high levels of AGK. High expression of AGK was associated with significantly shorter overall and disease-free survival (P < 0.001 and P = 0.002; log-rank test) and was an independent prognostic factor for overall survival (P = 0.041; multivariate Cox analysis). High AGK expression was associated with lymph node metastasis (P < 0.001; chi-squared test) and was an independent predicted factor for lymph node metastasis in NPC (P = 0.032; multivariate logistic analysis). AGK is overexpressed and associated with disease progression and lymph node metastasis in NPC. AGK has potential as a novel prognostic factor for overall survival in NPC.