Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin
Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin
复制标题
枯草杆菌蛋白酶消化的破伤风毒素抗体的毒素中和作用
作者：
H. Sato;A. Ito;Y. Yamakawa;R. Murata
在左大腿注射破伤风毒素和抗体的混合物的小鼠中观察到一种具有非典型症状的全身性破伤风，所述抗体是在豚鼠中产生的，所述抗体针对从结晶毒素的枯草杆菌蛋白酶消化物中获得的毒素片段。小鼠未表现出局部破伤风的典型症状，如注射肢体的惊厥或痉挛性麻痹。
A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.