Thalamocingulate Interactions In Performance Monitoring
Thalamocingulate Interactions In Performance Monitoring
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DOI：
10.1523/jneurosci.6242-10.2011
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发表时间：
2011-03-02
影响因子：
5.3
通讯作者：
Ullsperger, Markus
中科院分区：
文献类型：
--
作者：
Seifert, Sebastian;von Cramon, D. Yves;Ullsperger, Markus
绩效监控是成功的目标导向行为的必要前提。过去二十年的研究表明，人类内侧额叶皮层的前中扣带皮层（aMCC）和额纹状体基底神经节回路参与了这一功能。在这里，我们讨论了丘脑在检测错误和相应地调整行为中的功能。使用基于扩散的纤维束成像，我们发现，在丘脑核团中，腹前（VA）和腹外侧前（VLa）核与aMCC的连接性相对较强。局部丘脑病变的患者表现出减少错误相关的消极，行为错误检测，和postterror调整。当病变特别影响丘脑VA/VLa核时，这些影响显著显著，这反映在完全不存在错误相关的负性。这些结果表明，丘脑，特别是其VA/VLa区域，是一个必要的组成部分的性能监测网络，解剖学上连接良好，功能上密切互动的aMCC。
Performance monitoring is an essential prerequisite of successful goal-directed behavior. Research of the last two decades implicates the anterior midcingulate cortex (aMCC) in the human medial frontal cortex and frontostriatal basal ganglia circuits in this function. Here, we addressed the function of the thalamus in detecting errors and adjusting behavior accordingly. Using diffusion-based tractography, we found that, among the thalamic nuclei, the ventral anterior (VA) and ventral lateral anterior (VLa) nuclei have the relatively strongest connectivity with the aMCC. Patients with focal thalamic lesions showed diminished error-related negativity, behavioral error detection, and posterror adjustments. When the lesions specifically affected the thalamic VA/VLa nuclei, these effects were significantly pronounced, which was reflected by the complete absence of the error-related negativity. These results reveal that the thalamus, particularly its VA/VLa region, is a necessary constituent of the performance-monitoring network, anatomically well connected and functionally closely interacting with the aMCC.