Detection of Multiple Parallel Transmission Outbreak of Streptococcus suis Human Infection by Use of Genome Epidemiology, China, 2005.
Detection of Multiple Parallel Transmission Outbreak of Streptococcus suis Human Infection by Use of Genome Epidemiology, China, 2005.
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DOI：
10.3201/eid2302.160297
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发表时间：
2017-02
影响因子：
11.8
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Du P;Zheng H;Zhou J;Lan R;Ye C;Jing H;Jin D;Cui Z;Bai X;Liang J;Liu J;Xu L;Zhang W;Chen C;Xu J
猪链球菌序列7型出现，并在1998年和2005年引起了中国两次最大规模的人类感染暴发。为了确定感染的主要危险因素和来源，我们分析了95个暴发相关分离株的全基因组，鉴定了160个单核苷酸多态性，并将其分为6个分支。分子钟分析显示，分支1（导致1998年爆发）于1997年10月出现。分支2-6（导致2005年爆发）在2002年2月至2004年8月期间分别出现。到2004年底，猪链球菌总共出现了41个谱系，并在6月爆发时通过单碱基突变迅速扩展到68个基因组类型2005年，我们鉴定出32个相同的分离株，并将它们分为8组，这些组分布在一个大的地理区域，没有传播联系。这些发现表明，人们在各自的地理位置同时被感染。
Streptococcus suis sequence type 7 emerged and caused 2 of the largest human infection outbreaks in China in 1998 and 2005. To determine the major risk factors and source of the infections, we analyzed whole genomes of 95 outbreak-associated isolates, identified 160 single nucleotide polymorphisms, and classified them into 6 clades. Molecular clock analysis revealed that clade 1 (responsible for the 1998 outbreak) emerged in October 1997. Clades 2–6 (responsible for the 2005 outbreak) emerged separately during February 2002–August 2004. A total of 41 lineages of S. suis emerged by the end of 2004 and rapidly expanded to 68 genome types through single base mutations when the outbreak occurred in June 2005. We identified 32 identical isolates and classified them into 8 groups, which were distributed in a large geographic area with no transmission link. These findings suggest that persons were infected in parallel in respective geographic sites.