Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse
Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse
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DOI：
10.1016/j.fct.2011.04.007
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发表时间：
2011-09-01
影响因子：
4.3
通讯作者：
Pandey, Maneesha
中科院分区：
文献类型：
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作者：
Agrawal, S. S.;Saraswati, Sarita;Pandey, Maneesha
乳香酸（Boswelliic acid，BA）是从乳香树（Boswellia serrata，Burseraceae）中分离得到的一种三萜类化合物，具有很强的抗炎和抗癌活性。本研究旨在探讨BA对腹水和实体性埃利希瘤的可能作用。在肿瘤植入后14天通过量化腹水体积来评估腹水肿瘤发展，而在肿瘤植入后30天通过H&E和IHC来评估实体瘤。腹腔注射BA可显著抑制腹水型和实体型埃利希瘤模型。与对照小鼠相比，观察到这种抑制，腹水体积、实体瘤体积和体重减少。这些治疗也增加了荷瘤小鼠的存活率。VEGF和TNF-α水平降低，而IL-12水平在25 mg/kg BA处理下升高。此外，腹膜血管生成和微血管密度降低的结果显示了抗血管生成的潜力。肿瘤显微镜检查显示，在BA处理组中Bax和caspase 3的表达增加，表明药物通过激活促凋亡bcl-2家族和caspase-3诱导肿瘤细胞凋亡。本研究揭示了乳香酸的有效抗肿瘤特性，并可以进一步扩展到开发治疗癌症的治疗方案。(C)2011爱思唯尔有限公司保留所有权利。
Boswellic acid (BA), a triterpene, isolated from Boswellia serrata (Burseraceae) has been found to possess potent anti-inflammatory and anti-cancer activity. The present study aimed at exploring the possible role of BA on ascites and solid Ehrlich tumor. Ascitic tumor development was evaluated 14 d after tumor implantation by quantification of the ascitic fluid volume whereas solid tumor was evaluated after 30 d tumor implantation by H&E and IHC. The i.p. administration of BA significantly inhibited ascitic and solid Ehrlich tumor model. This inhibition was observed with reduced ascitic volume, solid tumor volume and body weight when compared to control mice. The treatments also increased the survival of tumor-bearing mice. VEGF and TNF- alpha levels were decreased, whereas the IL-12 levels were increased with BA treatment at 25 mg/kg. Further, results on decrease in the peritoneal angiogenesis and microvessel density showed the anti-angiogenic potential. Microscopic examination of tumors revealed that in BA-treated groups the expression of Bax and caspase 3 increased, suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3. The present study sheds light on the potent antitumor property of the boswellic acid and can be extended further to develop therapeutic protocols for treatment of cancer. (C) 2011 Elsevier Ltd. All rights reserved.