SEROTONIN TRANSPORTER POLYMORPHISM (5-HTTLPR) ASSOCIATION WITH MELANCHOLIC DEPRESSION: A FEMALE SPECIFIC EFFECT?
SEROTONIN TRANSPORTER POLYMORPHISM (5-HTTLPR) ASSOCIATION WITH MELANCHOLIC DEPRESSION: A FEMALE SPECIFIC EFFECT?
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DOI：
10.1002/da.20433
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发表时间：
2008-01-01
影响因子：
7.4
通讯作者：
Domschke, Katharina
中科院分区：
文献类型：
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作者：
Baune, Bernhard T.;Hohoff, Christa;Domschke, Katharina
早期的研究对5-羟色胺转运体（5-HTT）基因变异与抑郁症之间的关联产生了不一致的结果，有证据表明5-HTTLPR对抑郁症与非典型抑郁症的差异效应。为了进一步阐明5-HTT基因变异对抑郁症精神病理学的影响，在这项分析中，研究了340名患有重性抑郁发作（DSM-IV）的白人患者中5-HTTLPR和功能密切相关的5-HTT rs 25531的影响，特别关注抑郁症的亚型（抑郁症与非典型抑郁症）应用logistic回归模型调整年龄和性别。纯合子、更活跃的5-HTTLPR LL基因型与抑郁症显著相关（优势比，OR，1.7; 95%可信区间，CI，1.1-2.6; P = 0.04），其作用起源于女性患者亚组（OR 1.9; 95%CI 1.0-3.4; P = 0.05）。此外，更活跃的5-HTTLPR/5-HTT rs 25531单倍型LALA表达了抑郁症的显著风险（OR 2.0; 95%CI 1.3-3.1; P = 0.001），同样仅在女性患者子样本中（OR 2.1; 95%CI 1.1- 4.1; P = 0.02）。目前的研究结果提供了进一步的支持，遗传变异增加血清素转运体活性与抑郁症的抑郁症亚型，以及潜在的女性特异性机制的证据，这种影响的关联。抑郁和焦虑25：920-925，2008. (C)2007 Wiley-Liss，Inc.
Earlier studies yielded inconsistent results on the association between variation in the serotonin transporter (5-HTT) gene and depression, with evidence for a differential effect of the 5-HTTLPR on melancholic versus atypical depression. To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender. The homozygous, more active 5-HTTLPR LL genotype was significantly associated with melancholic depression (odds ratio, OR, 1.7; 95% confidence interval, CI, 1.1-2.6; P = 0.04), with the effect originating in the female subgroup of patients (OR 1.9; 95%CI 1.0-3.4; P = 0.05). Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype LALA conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P = 0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1- 4.1; P = 0.02). The present results provide further support for an association of genetic variation increasing serotonin transporter activity with the melancholic subtype of depression as well as evidence for a potential female-specific mechanism underlying this effect. Depression and Anxiety 25:920-925, 2008. (C) 2007 Wiley-Liss, Inc.