Improved synthesis and resolution of β-(3-pyridyl)-DL-α-alanine
Improved synthesis and resolution of β-(3-pyridyl)-DL-α-alanine
复制标题
改进 β-(3-吡啶基)-DL-α-丙氨酸的合成和分离
DOI：
--
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
J. Stȩpiński
中科院分区：
文献类型：
--
作者：
K. Folkers;T. Kubiak;J. Stȩpiński
以3-吡啶二醛为原料，经氮化内酯水解成丙烯酸，合成了-苯并脒-（3-吡啶基）- dl -丙氨酸盐酸盐。甲酯被枯草菌素有效分解。由于d -异构体用于合成促黄体生成素释放激素的拮抗剂，因此确定了d -异构体的光学纯度。
beta-Benzamido-alpha-(3-pyridyl)-DL-alpha-alanine hydrochloride was synthesized from 3-pyridinecarboxyaldehyde via the azlactone which was hydrolyzed to the acrylic acid before hydrogenation. The methyl ester was effectively resolved with subtilisin. The optical purity of the D-isomer was established, since the D-isomer was used in synthesis of antagonists of the luteinizing hormone releasing hormone.