Maternal determinants of gestation length in the rhesus monkey.
Maternal determinants of gestation length in the rhesus monkey.
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DOI：
10.31300/tdb.14.2021.63-72
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Lubach, Gabriele R
中科院分区：
文献类型：
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作者：
Coe, Christopher L;Lubach, Gabriele R
正常妊娠期和足月自然分娩被认为是健康妊娠的重要指标，特别是考虑到早产对新生儿的潜在不良后果。虽然许多人已经评估了影响人类妊娠期长短的因素，并且对驯养农场动物的妊娠期有相当大的兴趣，但最近在生物医学研究中最常用的灵长类动物恒河猴中尚未重新评估这一主题。在较早的文章中，它的妊娠期通常报告为165天，尽管大多数作者承认可能会在180天内怀孕。预测可接受的预产期的正常范围对于何时干预过期妊娠具有重要的兽医意义。使用档案记录从一个大的，既定的育种计划，妊娠长度和婴儿出生体重进行了分析，在25年的时间内，408怀孕。评估了母体因素（包括年龄和产次）的潜在影响。在母亲-女儿母系妊娠长度的家族一致性进行了检查，以及重复妊娠的84个经产女性的长度相似性。从交配到分娩的平均持续时间为168.8天，比大多数但不是所有先前文章中报告的时间长。许多女性在较长的时间内成功分娩，这可能促使考虑剖腹产。单个女性的妊娠时间相当稳定，并且在多胎妊娠中显著相关。有没有一个显着的跨代影响妊娠期的长度，即使生育小婴儿和大婴儿的家族倾向是明显的女性后代。典型的怀孕长度和出生体重作为参考标准，以协助其他育种计划，并提高我们对恒河猴的自然繁殖的理解，这些恒河猴仍然生活在南亚的许多森林和城市地区。
A gestation length of normal duration and natural delivery at term are considered to be important indicators of a healthy pregnancy, especially given the potentially adverse consequences for neonates of being born premature. While many have assessed the factors influencing gestation length in humans, and there has been considerable interest in the pregnancy duration of domesticated farm animals, this topic has not been re-assessed recently in rhesus monkeys, the most commonly used primate in biomedical research. In older articles, it’s gestation length was typically reported to be 165 days, although most authors acknowledged that viable pregnancies could occur out to 180 days. Predicting the normal range of acceptable due dates has important veterinary implications for when to intervene in a prolonged pregnancy. Using archival records from a large, established breeding program, gestation lengths and infant birthweights were analyzed for 408 pregnancies across a 25-year period. The potential influence of maternal factors, including age and parity, was assessed. Familial concordance in gestation length within mother-daughter matrilines was examined, as well as similarity in length across repeat pregnancies for 84 multiparous females. Mean duration from mating to delivery was 168.8 days, longer than reported in most but not all previous articles. Many females birthed successfully at a longer duration that might have prompted consideration of a caesarian delivery. Gestation length for an individual female was fairly stable and significantly correlated across multiple pregnancies. There was not a pronounced transgenerational influence on gestation length even though familial propensities for birthing small and large infants were evident in the female descendants. Typical pregnancy lengths and birthweights are provided as reference norms to assist other breeding programs and to enhance our understanding of the natural reproduction of rhesus macaques that still live in many forested and urban locations across South Asia.