Restoration of hand function in a rat model of repair of brachial plexus injury
Restoration of hand function in a rat model of repair of brachial plexus injury
复制标题
DOI：
10.1093/brain/awp030
复制
发表时间：
2009-05-01
期刊：
影响因子：
14.5
通讯作者：
Li, Ying
中科院分区：
文献类型：
--
作者：
Ibrahim, Ahmed G.;Kirkwood, Peter A.;Li, Ying
脊髓损伤和皮层下中风的不可治愈性是由于神经纤维不能再生。臂丛神经撕脱伤是临床上最明显的一种再生失败导致永久性功能缺陷的情况。在目前的实践中，撕脱的脊神经根的手术再植入提供了一定程度的运动恢复，但患者既没有恢复感觉也没有恢复手的使用。在目前的大鼠研究中，我们表明，移植培养的成年嗅鞘细胞恢复感觉输入所需的一个复杂的，目标导向的前爪功能，并重新建立突触传递到脊髓灰质和楔状核切断背根纤维再生到脊髓的桥梁。人类嗅鞘细胞在临床臂丛神经损伤中的首次成功应用将为脑和脊髓损伤的更广泛领域开辟道路。
The incurability of spinal cord injury and subcortical strokes is due to the inability of nerve fibres to regenerate. One of the clearest clinical situations where failure of regeneration leads to a permanent functional deficit is avulsion of the brachial plexus. In current practice, surgical re-implantation of avulsed spinal roots provides a degree of motor recovery, but the patients neither recover sensation nor the use of the hand. In the present rat study, we show that transplantation of cultured adult olfactory ensheathing cells restores the sensory input needed for a complex, goal-directed fore-paw function and re-establishes synaptic transmission to the spinal grey matter and cuneate nucleus by providing a bridge for regeneration of severed dorsal root fibres into the spinal cord. Success in a first application of human olfactory ensheathing cells in clinical brachial plexus injury would open the way to the wider field of brain and spinal cord injuries.