A new saxitoxin analogue from a xanthid crab Atergatis floridus
A new saxitoxin analogue from a xanthid crab Atergatis floridus
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DOI：
10.1016/0041-0101(95)00106-9
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发表时间：
1995-12-01
期刊：
影响因子：
2.8
通讯作者：
Onoue, Y
中科院分区：
文献类型：
--
作者：
Arakawa, O;Nishio, S;Onoue, Y
从栖息于四国岛太平洋沿岸的黄蟹 Atergatis floridus 的有毒标本中分离出一种新型麻痹毒素，基于高效液相色谱、电喷雾电离质谱以及 H-1 和 C-13-NMR 谱，推断其结构为 11-石房蛤毒素乙酸 (SEA)。假定该酸以三种互变异构体的平衡混合物形式存在，主要互变异构体是 11 β-差向异构体的水合物形式。 SEA 在腹腔注射中表现出每亩摩尔 830 小鼠单位的特异性毒性。注射到小鼠体内。
A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island, Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on highperformance liquid chromatography, electrospray ionization mass spectrometry, and H-1 and C-13-NMR spectrometries. This acid was assumed to exist as an equilibrium mixture of three tautomers, the main tautomer being the hydrate form of 11 beta-epimer. SEA showed a specific toxicity of 830 mouse units per mu mole on i.p. injection into mice.