Effect of a high protein meat diet on muscle and cognitive functions: A randomised controlled dietary intervention trial in healthy men
Effect of a high protein meat diet on muscle and cognitive functions: A randomised controlled dietary intervention trial in healthy men
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DOI：
10.1016/j.clnu.2010.12.010
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发表时间：
2011-06-01
影响因子：
6.3
通讯作者：
Roth, Erich
中科院分区：
文献类型：
--
作者：
Jakobsen, Lene H.;Kondrup, Jens;Roth, Erich
背景：有人建议使用氮平衡以外的其他标准来确定蛋白质的需要量。然而，很少有证据支持其他措施，如生理functions.Objective：调查的影响，一个普通的（UP）与高蛋白（HP）的饮食对肌肉功能，认知功能，生活质量和生化调节蛋白metabolis.Design：一个随机干预研究进行了23名健康男性（年龄19-31岁）。所有受试者在干预期前的1周导入期内食用蛋白质（UP）饮食（1.5 g蛋白质/kg BW），在干预期内，他们被分配到UP或高蛋白（HP）饮食（3.0 g蛋白质/kg BW），持续3周，控制食物和饮料的摄入。在基线和干预期结束时沿着采集血液和尿液样本，测量生理功能。结果：HP组与UP组相比，反应时显著改善。血浆中的支链氨基酸和苯丙氨酸显着增加后的HP饮食，这可以解释改善的反应时间。结论：健康的年轻男性喂HP饮食改善反应时间。没有观察到HP饮食的副作用。该试验在www.clinicaltrials.govasNCT00621231注册。(C)2010年爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background: Recommendations to use other criteria than N-balance for defining protein requirements have been proposed. However, little evidence to support other measures such as physiological functions is available.Objective: To investigate the effects of a usual (UP) versus a high protein (HP) diet on muscle function, cognitive function, quality of life and biochemical regulators of protein metabolism.Design: A randomised intervention study was conducted with 23 healthy males (aged 19-31 yrs). All subjects consumed a Usual Protein (UP) diet (1.5 g protein/kg BW) for a 1-wk run-in period before the intervention period where they were assigned to either a UP or a High Protein (HP) diet (3.0 g protein/kg BW) for 3-wks with controlled intake of food and beverages. Blood and urine samples were taken along with measurements of physiological functions at baseline and at the end of the intervention period.Results: The HP group improved their reaction time significantly compared with the UP group. Branched chain amino acids and phenylalanine in plasma were significantly increased following the HP diet, which may explain the improved reaction time.Conclusion: Healthy young males fed a HP diet improved reaction time. No adverse effects of the HP diet were observed.This trial was registered at www.clinicaltrials.govas NCT00621231. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.