Preliminary evidence that individuals with remitted alcohol use disorder and major depressive disorder exhibit enhanced neural responses to reward: An EEG study.
Preliminary evidence that individuals with remitted alcohol use disorder and major depressive disorder exhibit enhanced neural responses to reward: An EEG study.
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初步证据表明，酒精使用障碍和重度抑郁症缓解的个体对奖励的神经反应增强：一项脑电图研究。
DOI：
10.1016/j.addbeh.2023.107712
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发表时间：
2023
影响因子：
4.4
通讯作者：
Shankman,StewartA
中科院分区：
文献类型：
--
作者：
Crane,NataniaA;Li,LilianY;Brooks,JuliaM;Shankman,StewartA
奖励的神经反应中断与酒精使用障碍（AUD）和重度抑郁症（MDD）的风险有关。目前尚不清楚这些发现是否延伸到那些从AUD和MDD缓解的人，这是一个关键问题，因为缓解研究可以（a）排除由于当前症状的影响，并且（B）可以揭示潜在的性状样差异。rAUD（n = 54）、rMDD（n = 66）、rAUD + rMDD（n = 53）和社区对照组（CCG; n = 81）。参与者在脑电图（EEG）期间完成了一个有效的金钱奖励任务。多水平模型研究了事件相关电位和奖励和损失反应的时频指数的组间差异，即奖励积极性（RewP），反馈消极性（FN），奖励相关的δ功率和损失相关的θ功率。结果分析显示，rAUD + rMDD组的奖励相关δ活性显著高于其他三组（p值< 0.01），其彼此没有差异。敏感性分析显示，在控制了残余电流MDD和AUD症状后，这种关系略高于设定的显著性阈值（p= 0.05）。有没有其他组的差异或显着的相互作用（p值> 0.05）conclusionsTo我们所知，这是第一个研究表明，与缓解的AUD和MDD的个人表现出增加的敏感性奖励相比，单独的AUD，MDD，没有AUD或MDD。这些研究结果表明，奖励的动机突出性可能是合并AUD和MDD的一个重要因素。
IntroductionDisruptions in neural responses to reward are implicated in risk for Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD). It is not clear whether these findings extend to those in remission from AUD and MDD, a critical question as studies of remission can (a) rule out effects due to current symptoms, and (b) can reveal potential trait-like differences.MethodsIndividuals with and without remitted AUD (rAUD) and/or rMDD (rMDD) were drawn from a larger study to create four groups: rAUD (n = 54), rMDD (n = 66), rAUD + rMDD (n = 53), and a community control group (CCG; n = 81). Participants completed a validated monetary reward task during electroencephalogram (EEG). Multilevel models examined group differences in event-related potentials and time–frequency indices of reward and loss responsiveness, namely, reward positivity (RewP), feedback negativity (FN), reward-related delta power, and loss-related theta power.ResultsAnalyses revealed that the rAUD + rMDD group had significantly higher reward-related delta activity than the three other groups (p-values< 0.01), which did not differ from each other. Sensitivity analyses revealed this relationship fell just above the threshold set for significance after controlling for residual current MDD and AUD symptoms (p=.05). There were no other group differences or significant interactions (p-values > 0.05).ConclusionsTo our knowledge, this is the first study to show that individuals with remitted AUD and MDD demonstrate increased sensitivity to rewards compared to individuals with remitted AUD alone, MDD alone, and without AUD or MDD. These findings suggest heightened motivational salience to reward might be an important factor in comorbid AUD and MDD.