A New Prognostic Risk Signature of Eight Ferroptosis-Related Genes in the Clear Cell Renal Cell Carcinoma.
A New Prognostic Risk Signature of Eight Ferroptosis-Related Genes in the Clear Cell Renal Cell Carcinoma.
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DOI：
10.3389/fonc.2021.700084
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发表时间：
2021
影响因子：
4.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Chen J;Zhan Y;Zhang R;Chen B;Huang J;Li C;Zhang W;Wang Y;Gao Y;Zheng J;Li Y
透明细胞肾细胞癌（ccRCC）是最常见的肾细胞癌，局部晚期预后较差。铁下垂是一种较新的细胞死亡类型，近年来引起了广泛的关注。本研究旨在探讨枯铁相关基因（FRGs）在ccRCC中的预后价值。本研究共检测到50个ccRCC与邻近正常肾组织差异表达的FRGs，其中26个与总生存期（OS）相关（P <0.05）。通过Lasso回归和多变量Cox回归分析筛选出8个最优frg，构建新的预后风险特征，预测ccRCC患者的预后。此外，该签名以显著优势通过预后生存分析的验证，并通过Cox回归分析确定风险评分为独立的预后指标。进一步的研究表明，该特征与免疫细胞浸润显著相关。此外，在ccRCC中检测了8种FRGs的水平。总的来说，8-FRG预后风险特征有助于临床医生预测患者的预后和OS，并规范预后评估。
Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma and has poor prognosis in the locally advanced stage. Ferroptosis, a relatively new type of cell death, has gained significant attention in recent years. This study aimed to explore the prognostic value of ferroptosis-related genes (FRGs) in ccRCC. In this study, 50 differentially expressed FRGs between ccRCC and adjacent normal kidney tissues were identified, 26 of them correlated with overall survival (OS) (P <0.05). Eight optimal FRGs were selected by Lasso regression and multivariate Cox regression analysis, and used to construct a new prognostic risk signature to predict the prognosis of ccRCC patients. In addition, the signature passed the validation of prognostic survival analyses by a significant margin, and the risk score was identified as an independent prognostic marker via Cox regression analyses. Further studies indicated that the signature was significantly correlated with immune cell infiltration. Moreover, the levels of eight FRGs were examined in ccRCC. Collectively, the 8-FRG prognostic risk signature helps the clinicians predict the prognosis and OS of the patients, and standardize prognostic assessments.
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