SECRETION OF ISLET AMYLOID POLYPEPTIDE IN RESPONSE TO GLUCOSE
SECRETION OF ISLET AMYLOID POLYPEPTIDE IN RESPONSE TO GLUCOSE
复制标题
DOI：
10.1016/0014-5793(89)81527-3
复制
发表时间：
1989-12-18
期刊：
影响因子：
3.5
通讯作者：
ADACHI, M
中科院分区：
文献类型：
--
作者：
KANATSUKA, A;MAKINO, H;ADACHI, M
用放射免疫法测定了大鼠胰岛中淀粉样多肽（IAPP）的含量。反相高效液相色谱分析显示，胰岛提取物中IAPP免疫反应性的主峰对应于合成的大鼠IAPP。细胞分泌IAPP受细胞外葡萄糖浓度的调节。因此，IAPP可能是一种新的葡萄糖稳态调节剂，其分泌变化可能与2型糖尿病中胰岛淀粉样蛋白沉积和葡萄糖耐量受损有关。
The content of isolet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse‐phase high‐performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.