Spike-Phase Coding Boosts and Stabilizes Information Carried by Spatial and Temporal Spike Patterns
Spike-Phase Coding Boosts and Stabilizes Information Carried by Spatial and Temporal Spike Patterns
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DOI：
10.1016/j.neuron.2009.01.008
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发表时间：
2009-02-26
期刊：
影响因子：
16.2
通讯作者：
Panzeri, Stefano
中科院分区：
文献类型：
--
作者：
Kayser, Christoph;Montemurro, Marcelo A.;Panzeri, Stefano
为了解释神经元是如何编码感觉信息的，已经提出了几种神经编码。在这里，我们测试了这样的假设，即不同的代码可能同时使用，并提供互补的刺激信息。我们量化了警觉动物的听觉皮质中关于自然声音的编码信息，发现时间棘波训练模式和空间种群都具有很高的信息量。然而，这些(时间或群体)反应发生的缓慢持续节律的相对阶段提供了许多额外和补充的信息。这种将棘波训练模式与放电阶段相结合的嵌套编码不仅提供了最多的信息，而且对增加到刺激中的感觉噪音也最稳健。我们的发现表明，感觉皮层的处理可能依赖于同时使用几个代码，这些代码将不同时空尺度上的信息结合在一起。此外，他们提出了慢的大脑皮层节律在通过减少噪音的影响来稳定感觉表征方面的作用。
Several neural codes have been proposed in order to explain how neurons encode sensory information. Here we tested the hypothesis that different codes might be employed concurrently and provide complementary stimulus information. Quantifying the information encoded about natural sounds in the auditory cortex of alert animals, we found that temporal spike-train patterns and spatial populations were both highly informative. However, the relative phase of slow ongoing rhythms at which these (temporal or population) responses occurred provided much additional and complementary information. Such nested codes combining spike-train patterns with the phase of firing were not only most informative, but also most robust to sensory noise added to the stimulus. Our findings suggest that processing in sensory cortices could rely on the concurrent use of several codes that combine information across different spatiotemporal scales. In addition, they propose a role of slow cortical rhythms in stabilizing sensory representations by reducing effects of noise.