Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.
Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.
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DOI：
10.1161/circresaha.122.320952
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发表时间：
2022-08-05
影响因子：
20.1
通讯作者：
Mora, Samia
中科院分区：
文献类型：
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作者：
Hoshi, Rosangela A.;Liu, Yanyan;Luttmann-Gibson, Heike;Tiwari, Saumya;Giulianini, Franco;Andres, Allen M.;Watrous, Jeramie D.;Cook, Nancy R.;Costenbader, Karen H.;Okereke, Olivia, I;Ridker, Paul M.;Manson, JoAnn E.;Lee, I-Min;Vinayagamoorthy, Manickavasagar;Cheng, Susan;Copeland, Trisha;Jain, Mohit;Chasman, Daniel, I;Demler, Olga, V;Mora, Samia
为了阐明体力活动(PA)相关心脏保护的机制，我们研究了PA与血浆生物活性脂(BALS)和心血管疾病(CVD)事件的关系。此外，我们还进行了全基因组关联。PA-BAL相关性在VITAL-CTSC(NCT01169259；N=1,032)中得到检验，并在JUPITER-NC(NCT00239681；N=589)中得到验证，使用根据年龄、性别、种族、低密度脂蛋白胆固醇、总胆固醇和吸烟进行调整的线性模型。在两个嵌套的心血管病病例对照研究中，进行了有意义的BALS以检查与心血管事件的相关性：VITAL-CVD(741个病例对照对)和Jupiter-CVD(415个病例对照对；验证)。我们检测到145个PA-BAL验证关联(FDR<；0.1)。在其中6个BALL中发现了注释：12，13-diHOME，9，10-diHOME，lysoPC(15：0)，羟吗酮-3b-D-葡萄糖醛酸脂，可的松和油酰甘油。JUPITER-NC内的遗传分析表明，32个与PA相关的BALL与22个SNP相关联。来自PA相关的BALL，12例与心血管疾病有关。我们确定了一个与PA相关的生物活性脂质体谱，其中12个BAL与心血管事件也有相反的关联。
To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations. PA-BAL associations were examined in VITAL-CTSC (NCT01169259; N=1,032) and validated in JUPITER-NC (NCT00239681; N=589), using linear models adjusted for age, sex, race, LDL-C, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in two nested CVD case-control studies: VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation). We detected 145 PA-BAL validated associations (FDR < 0.1). Annotations were found for 6 of these BALs: 12,13-diHOME, 9,10-diHOME, lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 SNPs. From PA-related BALs, 12 associated with CVD. We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.