Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "Top-Down" approach to intestinal fibrosis in mice.
Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "Top-Down" approach to intestinal fibrosis in mice.
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DOI：
10.1002/ibd.21812
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发表时间：
2012-03
影响因子：
4.9
通讯作者：
Higgins, Peter D. R.
中科院分区：
文献类型：
--
作者：
Johnson, Laura A.;Luke, Amy;Sauder, Kay;Moons, David S.;Horowitz, Jeffrey C.;Higgins, Peter D. R.
关键词：
The natural history of Crohn’s disease follows a path of progression from an inflammatory to a fibrostenosing disease, with most patients requiring surgical resection of fibrotic strictures. Potent anti-inflammatory therapies reduce inflammation but do not appear to alter the natural history of intestinal fibrosis. The aim of this study was to determine the relationship between intestinal inflammation and fibrogenesis and the impact of a very early “top-down” interventional approach on fibrosis in vivo. In this study, we removed the inflammatory stimulus from the Salmonella typhimurium mouse model of intestinal fibrosis by eradicating the S. typhimurium infection with levofloxacin at sequential time points during the infection. We evaluated the effect of this elimination of the inflammatory stimulus on the natural history of inflammation and fibrosis as determined by gross pathology, histopathology, mRNA expression, and protein expression. Fibrogenesis is preceded by inflammation. Delayed eradication of the inflammatory stimulus by antibiotic treatment represses inflammation without preventing fibrosis. Early intervention significantly ameliorates but does not completely prevent subsequent fibrosis. This study demonstrates that intestinal fibrosis develops despite removal of an inflammatory stimulus and elimination of inflammation. Early intervention ameliorates but does not abolish subsequent fibrosis, suggesting that fibrosis, once initiated, is self-propagating, suggesting that a very early “top-down” interventional approach may have the most impact on fibrostenosing disease.
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影响因子：
2.5
作者：
Strober W;Zhang F;Kitani A;Fuss I;Fichtner-Feigl S
通讯作者：
Fichtner-Feigl S
影响因子：
14.8
作者：
Wirtz, Stefan;Neufert, Clemens;Neurath, Markus F.
通讯作者：
Neurath, Markus F.
影响因子：
9
作者：
Jones, Douglas W.;Finlayson, Samuel R. G.
通讯作者：
Finlayson, Samuel R. G.
影响因子：
9.8
作者：
Sands, BE;Arsenault, JE;Zawacki, JK
通讯作者：
Zawacki, JK
DOI：
10.1016/j.cimid.2010.12.002
发表时间：
2011-05-01
影响因子：
2
作者：
Higgins, Peter D. R.;Johnson, Laura A.;Wobus, Christiane E.
通讯作者：
Wobus, Christiane E.