Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
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DOI：
10.1152/jappl.2000.89.1.104
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发表时间：
2000-07-01
影响因子：
3.3
通讯作者：
Ross, R
中科院分区：
文献类型：
--
作者：
Goodpaster, BH;Kelley, DE;Ross, R
本研究的目的是验证计算机断层扫描 (CT) 体内骨骼肌衰减 (MA) 测量与肌肉脂质含量相关。对不同脂质浓度的模型进行的单层 CT 扫描显示衰减和脂质浓度之间具有良好的一致性 (r(2) = 0.995)；将体模的脂质浓度增加 1 g/100 ml，其衰减量减少了大约 1 个 Hounsfield 单位 (HU)。对 6 名志愿者进行的两次 CT 扫描的重测变异系数，大腿中部为 0.51%，小腿中部为 0.85%，表明方法学变异性较低。瘦受试者的 MA 值 (49.2 +/- 2.8 HU) 显着高于肥胖非糖尿病受试者 (39.3 +/- 7.5 HU) 和肥胖 2 型糖尿病受试者 (33.9 +/- 4.1 HU)，而肥胖 2 型糖尿病受试者的 MA 值较低，与肥胖非糖尿病受试者没有差异。志愿者亚组中大腿中部和小腿中部的 MA（r = 0.60，P < 0.01）、腰肌（r = 0.65，P < 0.01）和竖脊肌（r = 0.17，P < 0.01）之间也存在良好的一致性。在 45 名从瘦到肥胖的男性和女性（体重指数 = 18.5 至 35.9 kg/m(2)）（包括 10 名 2 型糖尿病患者）中，MA 减少与组织学油红 O 染色测定的肌纤维脂质含量增加相关（P = -0.43，P < 0.01）。在这些志愿者的子集中 (Pt = 19)，股外侧肌经皮活检标本中的甘油三酯含量也与 MA 相关 (r = -0.58，P = 0.019)。我们的结论是，通过 CT 测定的骨骼肌体内衰减与其脂质含量有关，这种非侵入性方法可以提供有关肌肉成分和肌肉功能之间关联的额外信息。
The purpose of this investigation was to validate that in vivo measurement of skeletal muscle attenuation (MA) with computed tomography (CT) is associated with muscle Lipid content. Single-slice CT scans performed on phantoms of varying lipid concentrations revealed good concordance between attenuation and lipid concentration (r(2) = 0.995); increasing the phantom's Lipid concentration by 1 g/100 ml decreased its attenuation by similar to 1 Hounsfield unit (HU). The test-retest coefficient of variation for two CT scans performed in six volunteers was 0.51% for the midthigh and 0.85% for the midcalf, indicating that the methodological variability is low. Lean subjects had significantly higher (P < 0.01) MA values (49.2 +/- 2.8 HU) than did obese nondiabetic (39.3 +/- 7.5 HU) and obese Type 2 diabetic (33.9 +/- 4.1 HU) subjects, whereas obese Type 2 diabetic subjects had lower MA values that were not different from obese nondiabetic subjects. There was also good concordance between MA in midthigh and midcalf (r = 0.60, P < 0.01), psoas (r = 0.65, P < 0.01), and erector spinae (r = 0.17, P < 0.01) in subsets of volunteers. In 45 men and women who ranged from lean to obese (body mass index = 18.5 to 35.9 kg/m(2)), including 10 patients with Type 2 diabetes mellitus, reduced MA was associated with increased muscle fiber lipid content determined with histological oil red O staining (P = -0.43, P < 0.01). In a subset of these volunteers (Pt = 19), triglyceride content in percutaneous biopsy specimens from vastus lateralis was also associated with MA (r = -0.58, P = 0.019). We conclude that the attenuation of skeletal muscle in vivo determined by CT is related to its lipid content and that this noninvasive method may provide additional information regarding the association between muscle composition and muscle function.