IS THERE A ROLE OF ACTH IN INCREASED CHOROIDAL THICKNESS IN CUSHING SYNDROME?
IS THERE A ROLE OF ACTH IN INCREASED CHOROIDAL THICKNESS IN CUSHING SYNDROME?
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DOI：
10.1097/iae.0000000000001198
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发表时间：
2017-03-01
影响因子：
3.3
通讯作者：
Mirza, Galip Ertugrul
中科院分区：
文献类型：
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作者：
Karaca, Cagatay;Karaca, Zuleyha;Mirza, Galip Ertugrul
目的：目的：应用增强深度成像光学相干断层扫描（OCT）技术评价库欣综合征（CS）患者脉络膜厚度（CT）。将Erciyes大学内分泌科3年内收治的新诊断CS患者与年龄和性别匹配的健康志愿者进行比较。结果：CS组各测点的脉络膜厚度均高于对照组，CS组各测点的厚度均高于对照组。然而，发现在中央凹中心（367.8 +/- 94.4 μ m对329 +/- 90.5 μ m）和中央凹颞侧1,000 μ m处的差异是显著的。促肾上腺皮质激素（ACTH）依赖性CS组在所有测量点的脉络膜厚度测量值均显著高于对照组（中央凹CT为388.2 +/- 92.4 μ m vs. 329.1 +/- 90.5 μ m）。结论：库欣综合征患者CT值增高，CT值与ACTH水平呈正相关。ACTH依赖性CS可能比ACTH非依赖性CS增加CT。这种效应可能与ACTH本身或血浆皮质醇水平升高或两者直接相关。
Purpose: To evaluate choroidal thickness (CT) in patients with Cushing syndrome (CS) with enhanced depth imaging optical coherence tomography.Methods: Twenty-eight patients with CS and 38 healthy volunteers were enrolled in this observational cross-sectional study. Patients with newly diagnosed CS who have been admitted to Erciyes University Department of Endocrinology in 3 years time interval were compared with age-and sex-matched healthy volunteers. Choroidal thickness was measured at the fovea and 2 points nasal and 2 points temporal to the fovea with 500mm intervals each.Results: Choroidal thickness measurements were higher in patients with CS than in the control group at all examination points; however, the difference was found to be significant at the center of the fovea (367.8 +/- 94.4 m mu m vs. 329 +/- 90.5 mu m) and 1,000 mu m temporal to the fovea. Choroidal thickness measurements were significantly higher in adrenocorticotrophic hormone (ACTH)-dependent CS group than in the control group at all measurement points (CT at fovea 388.2 +/- 92.4 mu m vs. 329.1 +/- 90.5 mu m). All CT measurements were found to be correlated with ACTH levels.Conclusion: Cushing syndrome is associated with increased CT. The ACTH-dependent CS may increase CT more than ACTH-independent CS. This effect may be directly related to ACTH itself or increased plasma cortisol levels or both.