HMG modifications and nuclear function.

HMG modifications and nuclear function.
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DOI:
10.1016/j.bbagrm.2009.11.009
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发表时间:
2010-01
影响因子:
4.7
通讯作者:
Wang, Yinsheng
Wang, Yinsheng
中科院分区:
生物学2区
文献类型:
--
作者:
Zhang, Qingchun;Wang, Yinsheng

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高迁移率族(HMG)蛋白在调节染色质动力学、基因转录活性和其他细胞过程中发挥重要作用。HMG蛋白的翻译后修饰可以改变它们与DNA和蛋白质的相互作用,从而影响它们的生物学活性。虽然这些修饰参与调节不同细胞环境中的生物过程的机制还不完全清楚,但随着人们对这些蛋白质功能的日益了解,对这些修饰“密码”的新见解已经出现。本文就哺乳动物HMG蛋白的化学修饰及其在核功能中的作用作一综述。
High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA and proteins, and consequently, affect their biological activities. Although the mechanisms through which these modifications are involved in regulating biological processes in different cellular contexts are not fully understood, new insights into these modification “codes” have emerged from the increasing appreciation of the functions of these proteins. In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions.
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