HMG modifications and nuclear function.
HMG modifications and nuclear function.
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DOI:
10.1016/j.bbagrm.2009.11.009
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发表时间:
2010-01
影响因子:
4.7
通讯作者:
Wang, Yinsheng
中科院分区:
文献类型:
--
作者:
Zhang, Qingchun;Wang, Yinsheng
High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA and proteins, and consequently, affect their biological activities. Although the mechanisms through which these modifications are involved in regulating biological processes in different cellular contexts are not fully understood, new insights into these modification “codes” have emerged from the increasing appreciation of the functions of these proteins. In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions.
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