Sex Differences in Prevalence and Comorbidity of Alcohol and Drug Use Disorders: Results From Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions
Sex Differences in Prevalence and Comorbidity of Alcohol and Drug Use Disorders: Results From Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions
复制标题
DOI：
10.15288/jsad.2012.73.938
复制
发表时间：
2012-11-01
影响因子：
3.4
通讯作者：
Grant, Bridget F.
中科院分区：
文献类型：
--
作者：
Goldstein, Rise B.;Dawson, Deborah A.;Grant, Bridget F.
目的：本研究考察了DSM-1V酒精使用障碍(AUDS)和药物使用障碍(DUDS)在普通美国成年人中的终生轴心I和II精神共病的性别差异。方法：利用全国酒精及相关疾病流行病学调查第1波和第2波的数据，比较男性和女性中每种疾病合并酒精滥用、酒精依赖、药物滥用和药物依赖的终生患病率。使用Logistic回归分析了酒精、任何药物、大麻和可卡因特有的滥用和依赖与每种共病障碍之间的性别相关性，首先调整了社会人口变量，然后对所有其他精神障碍进行了额外调整。结果：在AUD和DUD的受试者中，大多数共病障碍的患病率因性别而有显著差异。然而，在调整了社会人口学特征和其他共同发生的精神疾病诊断后，在特定AUD和DUD与特定精神障碍的独特共病关联中，性别差异很小。结论：精神障碍与AUDS和DUDS并存的比率表明，两性的发病率负担都很大，这突显了对药物使用和精神健康障碍进行仔细评估和适当治疗的必要性。这项研究中发现的与AUD和DUD的独特共病关联进一步表明，需要进行前瞻性病因学研究来表征这些关联、它们的潜在机制以及这些机制可能的性别特异性。(J螺柱.酒精类毒品，2012年，73,938-950)
Objective: The present study examined sex differences in lifetime Axis I and II psychiatric comorbidity of DSM-1V alcohol use disorders (AUDs) and drug use disorders (DUDS) among general population U.S. adults. Method: Using data from Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions, Wave 2 lifetime prevalences of each disorder comorbid with alcohol abuse, alcohol dependence, drug abuse, and drug dependence were compared between men and women. Sex-specific associations of alcohol, any drug, and cannabis- and cocaine-specific abuse and dependence with each comorbid disorder were examined using logistic regression, first with adjustment for sociodemographic variables and then with additional adjustment for all other psychiatric disorders. Results: Prevalences of most comorbid disorders differed significantly by sex among respondents with each AUD and DUD. However, after adjustment for sociodemographic characteristics and additional co-occurring psychiatric diagnoses, there were few sex differences in unique comorbid associations of specific AUDs and DUDs with specific psychiatric disorders. Conclusions: Rates of psychiatric disorders comorbid with AUDs and DUDs indicate large burdens of morbidity in both sexes, highlighting the need for careful assessment and appropriate treatment of both substance use and mental health disorders. The unique comorbid associations with AUDs and DUDs identified in this study further indicate the need for prospective etiological research to characterize these associations, their underlying mechanisms, and the possible sex specificity of those mechanisms. (J Stud. Alcohol Drugs, 73, 938-950, 2012)