Genetic Determinants of Time Perception Mediated by the Serotonergic System
Genetic Determinants of Time Perception Mediated by the Serotonergic System
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DOI：
10.1371/journal.pone.0012650
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发表时间：
2010-09-17
期刊：
影响因子：
3.7
通讯作者：
Wackermann, Jiri
中科院分区：
文献类型：
--
作者：
Sysoeva, Olga V.;Tonevitsky, Alexander G.;Wackermann, Jiri
背景资料：本研究探讨神经生物学基础的个体差异在时间perceive.Methodology：四十四右撇子俄罗斯白人男性（18-35岁）参加了实验。根据标准程序，在DNA分析的基础上确定与5-羟色胺（5-HT）和多巴胺（DA）系统（如5-HTT、5 HT 2a、MAOA、DAT、DRD 2、COMT）活性相关的基因的多态性。超秒范围内的时间知觉（平均持续时间4.8秒）进行了研究，使用持续时间歧视任务和心理测量功能的参数拟合，导致个人确定的主观平等点（PSE）。假设内部持续时间表示的“双klepsydra模型”，PSE值被转换成参数kappa（kappa）的等效值，该参数是持续时间表示的“损失率”的度量。时间表征参数（PSE和k，分别）和5-HT相关基因之间的关联被发现，但没有与DA相关基因。发现具有较高5-HT传递特征的基因型携带者的累积持续时间表征的较高“丢失率”（k），即，1)5-HT再摄取较低，已知5-HTTLPR SS多态性与LL相比，2）5-HT降解较低，MAOA VNTR基因的“低表达”变体与“高表达”变体相比，3）5-HT 2a受体密度较高，提出5-HT 2a T102 C基因的TT多态性与CC相比。本研究和以前的心理药理学研究的收敛结果表明，从5-HT活性相关基因的行动路径，通过5-HT在大脑中的活动，时间知觉。DA系统参与编码的持续时间在超秒范围内的质疑。
Background: The present study investigates neurobiological underpinnings of individual differences in time perception.Methodology: Forty-four right-handed Russian Caucasian males (18-35 years old) participated in the experiment. The polymorphism of the genes related to the activity of serotonin (5-HT) and dopamine (DA)-systems (such as 5-HTT, 5HT2a, MAOA, DAT, DRD2, COMT) was determined upon the basis of DNA analysis according to a standard procedure. Time perception in the supra-second range (mean duration 4.8 s) was studied, using the duration discrimination task and parametric fitting of psychometric functions, resulting in individual determination of the point of subjective equality (PSE). Assuming the 'dual klepsydra model' of internal duration representation, the PSE values were transformed into equivalent values of the parameter kappa (kappa), which is a measure of the 'loss rate' of the duration representation. An association between time representation parameters (PSE and k, respectively) and 5-HT-related genes was found, but not with DA-related genes. Higher 'loss rate' (k) of the cumulative duration representation were found for the carriers of genotypes characterized by higher 5-HT transmission, i.e., 1) lower 5-HT reuptake, known for the 5-HTTLPR SS polymorphism compared with LL, 2) lower 5-HT degradation, described for the 'low expression' variant of MAOA VNTR gene compared with 'high expression' variant, and 3) higher 5-HT2a receptor density, proposed for the TT polymorphism of 5-HT2a T102C gene compared with CC.Conclusion: Convergent findings of the present study and previous sychopharmacological studies suggest an action path from 5-HT-activity-related genes, via activity of 5-HT in the brain, to time perception. An involvement of the DA-system in the encoding of durations in the supra-second range is questioned.