BIOCHEMISTRY OF THE USTILAGINALES: I. PRELIMINARY CULTURAL STUDIES OF USTILAGO ZEAE
BIOCHEMISTRY OF THE USTILAGINALES: I. PRELIMINARY CULTURAL STUDIES OF USTILAGO ZEAE
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DOI：
10.1139/cjr50c-012
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发表时间：
1950-04
期刊：
影响因子：
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通讯作者：
R. Haskins
中科院分区：
文献类型：
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作者：
R. Haskins
一项广泛筛选真菌“发酵”葡萄糖和各种农业废弃物和剩余物的计划表明，黑穗病菌能够快速地同化碳水化合物，并产生(1)一种复杂的物质，在培养混合物中表现为长针状的光学活性晶体，(2)脂肪和甾醇，(3)一系列新的抗生素物质，称为Ustizeain A， B等。(1)和(2)的产量密切相关，它们共同构成黑穗病代谢副产物的主要部分。抗菌药物(3)在体外对革兰氏阳性菌如枯草芽孢杆菌和耻垢分枝杆菌稳定有效；抗革兰氏阴性布氏菌；并对许多真菌，包括黑曲霉和黄曲霉群，某些青霉菌，黄萎病菌和许多其他真菌不完美。
A program of screening a wide range of fungi for ability to "ferment" glucose and various agricultural wastes and surpluses in submerged culture revealed that species of Ustilago were capable of rapid dissimilation of carbohydrates with the production of (1) a complex substance appearing as long needlelike optically active crystals in the culture mixture, (2) fats and sterols, and (3) a range of new antibiotic substances designated as Ustizeain A, B, etc. The yields of (1) and (2) are closely related and together they constitute the major portion of the by-products of metabolism of the smut. The antibiotics (3) are stable and effective in vitro against Gram-positive bacteria such as Bacillus subtilis and Mycobacterium smegmatis; against Gram-negative Brucella bronchiseptica; and against many fungi including species of Aspergillus niger and A. flavus groups, certain penicillia, Verticillium, and many other Fungi Imperfecti.