Advanced analyses of computed tomography coronary angiography can help discriminate ischemic lesions
Advanced analyses of computed tomography coronary angiography can help discriminate ischemic lesions
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计算机断层扫描冠状动脉造影的高级分析有助于区分缺血性病变
DOI：
10.1016/j.ijcard.2018.04.020
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发表时间：
2018-09-15
影响因子：
3.5
通讯作者：
Zhong, Liang
中科院分区：
文献类型：
--
作者：
Zhang, Jun-Mei;Shuang, Dongsi;Zhong, Liang
背景：计算机断层冠状动脉造影（CTCA）图像分析使斑块表征和非侵入性血流储备（FFR）计算成为可能。我们分析了来自CTCA图像的各种参数，并评估了它们与缺血的关系。方法：49例（61例病变）行CTCA +有创FFR。病变直径狭窄(DS) >= 50%为梗阻性病变。采用解析和数值相结合的CTCA图像处理方法，量化病灶长度（LL）和最小管腔面积（MLA）的解剖参数；斑块特征参数：斑块体积、低衰减斑块（LAP）体积、致密钙体积（DCV）、归一化斑块体积（NP Vol）、斑块负荷、偏心率指数、餐巾环（NR）征象；血流动力学参数：阻力指数、狭窄血流储备（SFR）和FFRB。缺血定义为FFR = 50% vs
Background: Computed tomography coronary angiography (CTCA) image analysis enables plaque characterization and non-invasive fractional flow reserve (FFR) calculation. We analyzed various parameters derived from CTCA images and evaluated their associations with ischemia.Methods: 49 (61 lesions) patients underwent CTCA and invasive FFR. Lesions with diameter stenosis (DS) >= 50% were considered obstructive. CTCA image processing incorporating analytical and numerical methods were used to quantify anatomical parameters of lesion length (LL) and minimum lumen area (MLA); plaque characteristic parameters of plaque volume, low attenuation plaque (LAP) volume, dense calcium volume (DCV), normalized plaque volume (NP Vol), plaque burden, eccentricity index and napkin-ring (NR) sign; and hemodynamic parameters of resistance index, stenosis flow reserve (SFR) and FFRB. Ischemia was defined as FFR = 50% vs