Ocular Surface - Merging Challenges and Opportunities.
Ocular Surface - Merging Challenges and Opportunities.
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DOI：
10.1167/tvst.9.12.3
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发表时间：
2020-11
影响因子：
3
通讯作者：
Yeung DT
中科院分区：
文献类型：
--
作者：
Araj H;Tumminia SJ;Yeung DT
二分法是一把双刃剑：它可以简化和启发，也可以夸大和纠缠。将眼睛视为前段与后段简化了解剖眼睛功能的艰巨任务。然而，这种观点在一个连贯的整体中制造了人为的分裂。显然，视觉需要眼睛前部的光折射功能与眼睛后部的光感测功能的会聚。国家眼科研究所长期以来一直致力于促进整个视觉通路的研究。找到正确的平衡是一项持续不断的工作。我们最近与美国陆军防化医学研究所共同组织了一次科学会议，提供了一个机会来评估眼前节，特别是眼表，为我们理解眼睛的生物学和疾病带来了什么。多重二分法浮出水面：急性与慢性疾病;上皮与内皮损伤;纤维化与血管病理学;炎症与消退反应;化学暴露与对策;单药治疗与联合治疗;机制研究与探索性研究;人类与动物模型。本文的目标就是将这些二分法合并起来。
Dichotomies are double-edged: they can simplify and enlighten as well as exaggerate and entangle. Seeing the eye as anterior segment vs. posterior segment simplifies the formidable task of dissecting the function of the eye. Yet this view creates artificial divisions in a coherent whole. Clearly, vision requires the convergence of the light refractive function of the front of the eye with the light sensing function of the back of the eye. The National Eye Institute has long aimed to foster research across the visual pathway. Finding the right balance is a constant work in progress. A recently held scientific meeting which we co-organized with the United States Army Medical Research Institute of Chemical Defense, offered an opportunity to take stock of what the anterior segment in general, and the ocular surface in particular, bring to our understanding of biology and disease of the eye. Multiple dichotomies surfaced: acute vs. chronic disease; epithelial vs. endothelial damage; fibrotic vs. vascular pathology; inflammation vs. resolution response; chemical exposure vs. countermeasure; monotherapy vs. combination therapy; mechanistic vs. exploratory research; human vs. animal model. Merging some of these dichotomies is the goal of this paper.