The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma.
The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma.
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DOI：
10.3390/jcm5060059
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发表时间：
2016-06-16
影响因子：
3.9
通讯作者：
Philip PA
中科院分区：
文献类型：
--
作者：
Diab M;Muqbil I;Mohammad RM;Azmi AS;Philip PA
胰腺导管腺癌（PDAC）仍然是一个非常具有挑战性的恶性肿瘤。在绝大多数患者中，疾病在晚期被诊断，并且PDAC细胞通常对常规细胞毒性药物具有抗性。与其他癌症不同，靶向治疗在治疗这种疾病方面没有取得进展。microRNAs（miRs）是一类非编码小分子RNA，通过靶向3′-UTR区域调控基因的表达。miRNAs的异常表达与多种恶性肿瘤的发生有关，包括PDAC。在PDAC中，一系列miR已被定义为具有早期诊断的前景，作为治疗抗性的指标，甚至作为患者治疗反应的标志物。在这篇简短的综述中，我们对PDAC生物学中定义的各种不同的miR进行了更新。
Pancreatic ductal adenocarcinoma (PDAC) remains a very challenging malignancy. Disease is diagnosed in an advanced stage in the vast majority of patients, and PDAC cells are often resistant to conventional cytotoxic drugs. Targeted therapies have made no progress in the management of this disease, unlike other cancers. microRNAs (miRs) are small non-coding RNAs that regulate the expression of multitude number of genes by targeting their 3′-UTR mRNA region. Aberrant expression of miRNAs has been linked to the development of various malignancies, including PDAC. In PDAC, a series of miRs have been defined as holding promise for early diagnostics, as indicators of therapy resistance, and even as markers for therapeutic response in patients. In this mini-review, we present an update on the various different miRs that have been defined in PDAC biology.