Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers.
Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers.
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DOI：
10.1111/ecc.12038
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发表时间：
2013-05
影响因子：
2.1
通讯作者：
Ishikawa H
中科院分区：
文献类型：
--
作者：
Nishimura S;Inada H;Sawa Y;Ishikawa H
本研究旨在探讨抗癌化疗中牙齿形成异常的危险因素。对接受常规化疗（n = 26）、常规化疗+大剂量化疗（HDC）（n = 14）和HDC+全身照射（TBI）（n = 6）治疗的长期生存者进行了分析，以了解牙齿发育不全、微小牙和短根牙的发生率。第二前磨牙和第二磨牙存在牙体发育不全和/或微小牙，而第一磨牙和中切牙未发现。在<4岁和≥ 4岁接受常规化疗的受试者中，牙齿发育不全和/或微小牙的受试者比例分别为66.7%和18.2%，而在<4岁和≥ 4岁接受HDC的受试者中，牙齿发育不全和/或微小牙的受试者比例分别为100%和25%。牙齿形成异常的发生率与常规化疗的持续时间无关，但HDC增加。牙齿形成异常的发生率在HDC合并和不合并TBI组之间没有显着差异，并且白消安组的发生率高于环磷酰胺组。结论：4岁以下儿童先天性牙发育不全是牙发育不全的高危人群。然而，常规化疗方案不是导致牙齿形成异常的重要危险因素。
This study aimed to investigate the risk factors of tooth formation anomalies in anti-cancer chemotherapies. Long-term survivors treated by conventional chemotherapy (n = 26), conventional chemotherapy with high-dose chemotherapy (HDC) (n = 14), and HDC with total body irradiation (TBI) (n = 6) were analysed for the incidence of tooth agenesis, microdonts, and short-rooted teeth. The tooth agenesis and/or microdonts were found in second premolars and second molars, but not in first molars or central incisors. The ratio of subjects with tooth agenesis and/or microdonts was 66.7% and 18.2% in subjects administered conventional chemotherapy at <4 years and ≥4 years of age, respectively, while it was 100% and 25% in subjects administered HDC at <4 years and ≥4 years of age. The incidence of tooth formation anomalies did not related with the duration of conventional chemotherapy but increased by HDC. The incidence of tooth formation anomalies did not show significantly differences between the HDC with and without TBI groups, and was higher in busulfan-administered subjects than in subjects given cyclophosphamide. It may be concluded that the high-risk group of tooth agenesis is the subjects with HDC under 4 years of age. However, protocols of conventional chemotherapy are not an important risk factor to cause the tooth formation anomalies.
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影响因子：
2.5
作者：
Endo, Toshiya;Yoshino, Sugako;Shimooka, Shohachi
通讯作者：
Shimooka, Shohachi
影响因子：
3.1
作者：
Voskuilen, I. G. M. van der Pas-van;Veerkamp, J. S. J.;Gortzak, R. A. Th.
通讯作者：
Gortzak, R. A. Th.
DOI：
10.17796/jcpd.33.3.c74j49r738676671
发表时间：
2009-03-01
影响因子：
1.3
作者：
Fujita, Yuko;Hidaka, Akiko;Maki, Kenshi
通讯作者：
Maki, Kenshi
影响因子：
6.2
作者：
Hsieh, Susan Gyea-Su;Hibbert, Sally;Arora, Manish
通讯作者：
Arora, Manish
影响因子：
3.4
作者：
Abe, Ryota;Endo, Toshiya;Shimooka, Shohachi
通讯作者：
Shimooka, Shohachi