Transmembrane B‐DNA
Transmembrane B‐DNA
复制标题
跨膜B-DNA
作者：
N. Sakai;B. Baumeister;S. Matile
跨膜(TM)通道内空间正引起越来越多的科学关注，因为周围双层膜的空间区隔提供了对通道内化学过程的矢量控制和随机可观测性。刚性棒b桶的卓越性能最近被用来合成稳定的大跨膜空间，在此之前，这似乎是大生物大分子独有的。TM内部1的特征是直径为2±3 nm和48个内源性赖氨酸残基，在拓扑和静电上与Watson±Crick B-DNA互补(图1)。类似的脉管内间隙有
Transmembrane (TM) intratoroidal space is attracting increasing scientific attention because the spatial compartmentalization by the surrounding bilayer membrane provides vectorial control over and stochastic observability of intratoroidal chemical processes. The superb properties of rigid-rod b-barrels 5] have very recently been used to synthesize large transmembrane space of a stability that seemed unique for large biomacromolecules until then. The TM interior of 1, characterized by a diameter of 2 ± 3 nm and 48 intratoroidal lysine residues, is topologically and electrostatically complementary to Watson ± Crick B-DNA (Figure 1). Similar intratoroidal space has