Cellular Mechanisms of Drosophila Heart Morphogenesis.
Cellular Mechanisms of Drosophila Heart Morphogenesis.
复制标题
果蝇心形形态发生的细胞机制。
DOI：
10.3390/jcdd2010002
复制
发表时间：
2015-03-01
影响因子：
2.4
通讯作者：
Bodmer R
中科院分区：
文献类型：
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作者：
Vogler G;Bodmer R
遗传学和发育生物学领域的许多重大发现都是利用果蝇（Drosophila melanogaster）取得的。在心脏发育方面，心脏发生背后的核心心脏转录因子的保守网络已经在果蝇中得到了非常详细的研究，一些调节心脏形态发生的信号通路的重要性，如Slit/Robo，首次在果蝇模型中得到证实。最近的技术进步导致先天性心脏病（CHD）患者可获得的基因组数据大量增加。这突出了一些潜在参与冠心病的候选基因和基因网络。验证基因和候选冠心病致病等位基因之间的遗传相互作用以及更好地了解心脏形成是主要任务。目前使用的各种心脏模型系统（哺乳动物和鱼类模型）的特定局限性为苍蝇模型提供了一个生态位，尽管它与脊椎动物和人类的进化距离较远。在这里，我们回顾了利用果蝇胚胎识别心脏形成相关因素的最新进展。这些都强调了这种模式生物对于更好地理解冠心病仍然是非常宝贵的。
Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, Drosophila melanogaster. With regard to heart development, the conserved network of core cardiac transcription factors that underlies cardiogenesis has been studied in great detail in the fly, and the importance of several signaling pathways that regulate heart morphogenesis, such as Slit/Robo, was first shown in the fly model. Recent technological advances have led to a large increase in the genomic data available from patients with congenital heart disease (CHD). This has highlighted a number of candidate genes and gene networks that are potentially involved in CHD. To validate genes and genetic interactions among candidate CHD-causing alleles and to better understand heart formation in general are major tasks. The specific limitations of the various cardiac model systems currently employed (mammalian and fish models) provide a niche for the fly model, despite its evolutionary distance to vertebrates and humans. Here, we review recent advances made using the Drosophila embryo that identify factors relevant for heart formation. These underline how this model organism still is invaluable for a better understanding of CHD.