White matter lesions and poor outcome after intracerebral hemorrhage A nationwide cohort study
White matter lesions and poor outcome after intracerebral hemorrhage A nationwide cohort study
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DOI：
10.1212/wnl.0b013e3181dd425a
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发表时间：
2010-05-11
期刊：
影响因子：
9.9
通讯作者：
Yoon, B. -W.
中科院分区：
文献类型：
--
作者：
Lee, S. -H.;Kim, B. J.;Yoon, B. -W.
背景资料：在脑出血（ICH）病例中，预测不良结局的能力对于患者护理和治疗决策非常重要。以前的研究包括相对较短的随访期和少量的患者，并限制在有关个人的大脑vulnerability.Methods的考虑方面：作者前瞻性地招募了全国33家医院的1,321例ICH患者。入院时收集临床、实验室和影像学变量，包括白色病变（WML）。采用入院时的格拉斯哥昏迷量表（GCS）总评分衡量ICH后即刻结局，采用30天死亡率衡量早期结局，采用死亡率相对风险衡量长期结局。2006年12月31日，使用韩国国家死亡证明确定入选患者的生命状态（平均随访时间为32.6个月）。结果：在纳入的1，321例ICH患者中，352例（27.8%）GCS评分为中度（8.5-12.4），249例（19.7%）GCS评分为重度（
Background: The ability to predict poor outcome is important for patient care and treatment decision-making in cases of intracerebral hemorrhage (ICH). Previous studies have included relatively brief follow-up periods and small numbers of patients, and are limited in terms of considerations regarding individual brain vulnerabilities.Methods: The authors prospectively enrolled 1,321 ICH patients nationwide from 33 hospitals. Clinical, laboratory, and imaging variables, including white matter lesions (WMLs), were collected at admission. Immediate outcome after ICH was measured using total Glasgow Coma Scale (GCS) score at admission, early outcome using 30-day mortality, and long-term outcome using relative risk for mortality. The vital status of included patients was ascertained on December 31, 2006, using Korean National Death Certificates (mean follow-up, 32.6 months).Results: Of the 1,321 ICH patients included, 352 (27.8%) presented with a moderate GCS score (8.5-12.4) and 249 (19.7%) with a severe GCS score (