V(D)J recombination in mature B cells: A mechanism for altering antibody responses
V(D)J recombination in mature B cells: A mechanism for altering antibody responses
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DOI：
10.1126/science.278.5336.298
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发表时间：
1997-10-10
期刊：
影响因子：
56.9
通讯作者：
Nussenzweig, MC
中科院分区：
文献类型：
--
作者：
Papavasiliou, F;Casellas, R;Nussenzweig, MC
克隆选择理论指出，产生高亲和力免疫球蛋白的 B 淋巴细胞是从经历抗体基因突变的细胞库中选择出来的。体细胞超突变是一种有据可查的机制，可实现成熟 B 细胞免疫反应的多样化。还发现抗体基因在生发中心的此类细胞中通过可变（V）、多样性（D）和连接（J）片段的重组而被修饰。在生发中心的选择性环境中通过 V(D)J 重组改变免疫球蛋白表达的能力可能是免疫反应失活或多样化的另一个机制。
The clonal selection theory states that B lymphocytes producing high-affinity immunoglobulins are selected from a pool of cells undergoing antibody gene mutation. Somatic hypermutation is a well-documented mechanism for achieving diversification of immune responses in mature B cells. Antibody genes were also found to be modified in such cells in germinal centers by recombination of the variable (V), diversity (D), and joining (J) segments. The ability to alter immunoglobulin expression by V(D)J recombination in the selective environment of the germinal center may be an additional mechanism for inactivation or diversification of immune responses.