Effects of ayahuasca on mental health and quality of life in naive users: A longitudinal and cross-sectional study combination
Effects of ayahuasca on mental health and quality of life in naive users: A longitudinal and cross-sectional study combination
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DOI：
10.1038/s41598-020-61169-x
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发表时间：
2020-03-05
影响因子：
4.6
通讯作者：
Carlos Bouso, Jose
中科院分区：
文献类型：
--
作者：
Jimenez-Garrido, Daniel F.;Gomez-Sousa, Maria;Carlos Bouso, Jose
Ayahuasca是一种致幻汤剂，在几个亚马逊地区被用作传统药物。死藤水的仪式性使用已在许多国家蔓延，因此有必要研究其风险和益处。本研究设计了两个子研究。在子研究1中，在第一次使用死藤水之前，对受试者（n = 40）进行了精神病学访谈和一系列问卷调查。在1个月和6个月时进行了两次随访。在子研究2中，同样的采访和电池的问卷管理长期ayahuasca用户（n = 23）和他们的分数进行了比较与ayahuasca天真组。在第一次评估中，发现近一半（45%）的初次使用者符合精神疾病的诊断标准。在使用ayahuasca后，超过80%的受试者表现出持续6个月的临床改善。问卷调查显示，抑郁症和精神病理学显著减少。关于子研究2，长期使用者表现出较低的抑郁评分，以及较高的自我超越和生活质量的分数，相比，他们的同龄人在子研究1。进一步的控制和观察自然主义研究评估ayahuasca的最终风险和潜在益处是必要的。
Ayahuasca is a hallucinogenic decoction used as a traditional medicine in several Amazonian regions. The ritualistic use of ayahuasca has spread throughout many countries, making it necessary to study its risks and benefits. Two sub-studies were designed for this investigation. In sub-study 1, a psychiatric interview and a battery of questionnaires were administered to subjects (n = 40) before their first ayahuasca use. Two follow-ups were conducted at 1 and 6 months. In sub-study 2, the same interview and battery of questionnaires were administered to long-term ayahuasca users (n = 23) and their scores were compared with those of the ayahuasca-naive group. In the first assessment, nearly half (45%) of the naive users were found to meet the diagnostic criteria for a psychiatric disorder. After the ayahuasca use, more than 80% of those subjects showed clinical improvements that persisted at 6 months. The questionnaires showed significant reductions in depression and psychopathology. Regarding substudy 2, long-term users showed lower depression scores, and higher scores for self-transcendence and quality of life, as compared to their peers in sub-study 1. Further controlled and observational naturalistic studies assessing the eventual risks and potential benefits of ayahuasca are warranted.