Effect of Tanreqing Injection ((sic)) on Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Chinese Medicine Syndrome of Retention of Phlegm and Heat in Fei ((sic))
Effect of Tanreqing Injection ((sic)) on Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Chinese Medicine Syndrome of Retention of Phlegm and Heat in Fei ((sic))
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痰热清注射液治疗慢性阻塞性肺疾病急性加重中医痰热蕴肺证疗效观察
DOI：
10.1007/s11655-010-0131-y
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发表时间：
2010-04-10
影响因子：
2.9
通讯作者：
Zheng Yu-qiong
中科院分区：
文献类型：
--
作者：
Li Wen;Mao Bing;Zheng Yu-qiong
Objective.探讨痰热清注射液（TRQI）治疗慢性阻塞性肺疾病急性加重期（AECOPD）痰热壅肺证的疗效。方法：在一项前瞻性随机对照临床试验中，将90例RPHF综合征AECOPD患者随机分为3组，TRQI组和对照组A和B，每箱30箱。TRQI组给予TRQI 20 mL静脉注射，1次/d，同时给予常规西药治疗。对照组A给予盐酸氨溴索15 mg静脉注射，2次/d，同时给予常规西药治疗，对照组B仅给予常规西药治疗，疗程均为10 d。观察两组患者中医症状、体征评分及血浆白细胞介素（IL）-8和中性粒细胞弹性蛋白酶（NE）水平。结果(1)治疗组中医症状（咳嗽、痰量、咳痰、气促、发热）和体征（舌脉）均明显改善（P
Objective. To explore the effect of Tanreqing Injection ((sic), TRQI) on the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with Chinese medicine syndrome of retention of phlegm and heat in Fei ((sic), RPHF) Methods: In a prospective randomized controlled clinical trial, 90 patients with AECOPD of RPHF syndrome were randomly assigned to 3 groups, TRQI and controls A and B, each with 30 cases. The TRQI group was administered with the intravenous injections of 20 mL TRQI once a day and conventional Western medicine treatment. Control group A was administered with the intravenous injection of 15 mg ambroxol hydrochloride twice a day and conventional Western medicine treatment, and control group B was administered with conventional Western medicine treatment only The treatments were administered for 10 days. Chinese medical symptoms and signs were scored, and plasma concentrations of interleukin (IL)-8 and neutrophil elastase (NE) were recorded. Results. (1) The Chinese medical symptoms (cough, sputum amount, expectoration, dyspnea and fever) and signs (tongue and pulse) improved significantly in the TRQI group (P