Three-dimensional DNA crystals as molecular sieves
Three-dimensional DNA crystals as molecular sieves
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DOI：
10.1021/ja061322r
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发表时间：
2006-05-31
影响因子：
15
通讯作者：
Paukstelis, Paul J.
中科院分区：
文献类型：
--
作者：
Paukstelis, Paul J.
DNA已被证明是一种成功的纳米级构建模块，因为它固有的可编程性和可预测的结构特征。DNA纳米技术的一个长期目标是合理设计和组装三维（3D）DNA晶体，用作分子支架、分子电子组装和分子筛。在这里，我们证明了合理设计的具有介孔特征的3D DNA晶体可以通过基于大小选择性地吸附蛋白质来起到分子筛的作用。
DNA has proved to be a successful nanoscale building block because of its inherent programmability and its predictable structural features. One long-standing goal of DNA nanotechnology has been the rational design and assembly of three-dimensional (3D) DNA crystals for use as molecular scaffolds, in molecular electronics assembly, and as molecular sieves. Here we demonstrate that rationally designed 3D DNA crystals with mesoporous features can function as molecular sieves by selectively adsorbing proteins based on size.