Molecular signatures of urinary cells distinguish acute rejection of renal allografts from urinary tract infection
Molecular signatures of urinary cells distinguish acute rejection of renal allografts from urinary tract infection
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DOI：
10.1097/01.tp.0000063931.08861.56
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发表时间：
2003-05-27
期刊：
影响因子：
6.2
通讯作者：
Suthanthiran, M
中科院分区：
文献类型：
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作者：
Dadhania, D;Muthukumar, T;Suthanthiran, M
急性排斥反应（AR）和尿路感染（UTI）一直困扰着肾移植患者.我们检验了UTI不增加尿细胞中颗粒酶B mRNA水平的假设，以及该水平区分AR和UTI的假设。我们检测了15例肾移植受者尿标本中颗粒酶B mRNA的水平，29例AR患者，但没有UTI，和14例患者，没有AR和没有UTI。我们还测量了41名非移植个体的尿液标本中的转录水平，其中11名患有UTI，30名没有UTI。UTI不增加颗粒酶B mRNA水平。移植肾后UTI组颗粒酶B mRNA水平低于AR组（P
Acute rejection (AR) and urinary tract infection (UTI) continue to plague renal transplantation. We tested the hypotheses that UTI does not increase granzyme B mRNA levels in urinary cells, and that the levels distinguish AR from UTI. We measured the levels of granzyme B mRNA in 15 urine specimens from renal allograft recipients with UTI, 29 specimens from patients with AR but without UTI, and 14 specimens from patients without AR and without UTI. We also measured transcript levels in urine specimens from 41 nontransplant individuals, 11 with UTI and 30 without UTI. UTI did not increase granzyme B mRNA levels. Granzyme B m-RNA levels were lower in renal allograft recipients with UTI compared with those with AR (P