A design framework for actively crosslinked filament networks
A design framework for actively crosslinked filament networks
复制标题
DOI：
10.1088/1367-2630/abd2e4
复制
发表时间：
2021-01-01
影响因子：
3.3
通讯作者：
Shelley, Michael J.
中科院分区：
文献类型：
--
作者：
Furthauer, Sebastian;Needleman, Daniel J.;Shelley, Michael J.
生物自身运动、变形和组织。在细胞中，这是由聚合物细丝和交联分子组成的网络实现的，这些网络将细丝彼此连接起来，并充当发动机在网络上做机械功。对于高交联丝网络的情况，我们讨论了组件的材料性质是如何从微观作用剂施加的力中出现的。首先，我们介绍了一个现象学模型，该模型描述了交联族在细丝之间施加的力。其次，我们推导出了一个理论，该理论可以在给定交联度的情况下预测高度交联度的纤维网络的材料性质。第三，我们讨论了交联剂的哪些性质决定了高交联性细胞骨架网络的材料性质和行为。这里介绍的工作将使人们能够更好地理解细胞骨架机制及其分子基础。这一理论也是朝着分子扰动如何影响细胞骨架组织的理论迈出的第一步，并为在实验室设计具有理想特性的细胞骨架网络提供了框架。
Living matter moves, deforms, and organizes itself. In cells this is made possible by networks of polymer filaments and crosslinking molecules that connect filaments to each other and that act as motors to do mechanical work on the network. For the case of highly cross-linked filament networks, we discuss how the material properties of assemblies emerge from the forces exerted by microscopic agents. First, we introduce a phenomenological model that characterizes the forces that crosslink populations exert between filaments. Second, we derive a theory that predicts the material properties of highly crosslinked filament networks, given the crosslinks present. Third, we discuss which properties of crosslinks set the material properties and behavior of highly crosslinked cytoskeletal networks. The work presented here, will enable the better understanding of cytoskeletal mechanics and its molecular underpinnings. This theory is also a first step toward a theory of how molecular perturbations impact cytoskeletal organization, and provides a framework for designing cytoskeletal networks with desirable properties in the lab.