Regulation of protein biogenesis at the endoplasmic reticulum membrane
Regulation of protein biogenesis at the endoplasmic reticulum membrane
复制标题
DOI：
10.1016/s0962-8924(99)01504-4
复制
发表时间：
1999-04-01
影响因子：
19
通讯作者：
Lingappa, VR
中科院分区：
文献类型：
--
作者：
Hegde, RS;Lingappa, VR
大多数分泌蛋白和膜蛋白的生物发生涉及将新生蛋白靶向内质网（ER），易位穿过或整合到ER膜中并成熟为功能产物。已经确定了指导模型分泌和膜蛋白这些事件的基本机制，将研究的重点转移到这些核心成分发挥作用的分子机制上。相比之下，允许某些蛋白质在细胞内发挥多种功能的调节机制仍然完全未被探索。本文探讨了蛋白质生物合成的每个阶段，作为一个潜在的网站的调节，可以利用细胞，以有效地增加功能基因表达的多样性。
The biogenesis of most secretory and membrane proteins involves targeting the nascent protein to the endoplasmic reticulum (ER), translocation across or integration into the ER membrane and maturation into a functional product. The essential machinery that directs these events for model secretory and membrane proteins has been identified, shifting the focus of studies towards the molecular mechanisms by which these core components function. By contrast, regulatory mechanisms that allow certain proteins to serve multiple functions within a cell remain entirely unexplored. This article examines each stage of protein biogenesis as a potential site of regulation that could be exploited by the cell to effectively increase the diversity of functional gene expression.