Visual-perceptual dysfunctions are possible endophenotypes of schizophrenia:: Evidence from the psychophysical investigation of magnocellular and parvocellular pathways
Visual-perceptual dysfunctions are possible endophenotypes of schizophrenia:: Evidence from the psychophysical investigation of magnocellular and parvocellular pathways
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DOI：
10.1037/0894-4105.19.5.649
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发表时间：
2005-09-01
期刊：
影响因子：
2.4
通讯作者：
Benedek, G
中科院分区：
文献类型：
--
作者：
Kéri, S;Kelemen, O;Benedek, G
精神分裂症患者及其亲生亲属的视觉信息处理能力受损。作者测量了72名精神分裂症患者、他们的86名兄弟姐妹和60名健康对照的游标阈值。受试者被要求检测两个刺激(左或右)的水平位移的方向。在巨细胞(M)通路测试中，刺激是低对比度的点(5%)或反相调制的栅格(25赫兹)。对于细小细胞(P)通路的测试，使用黄绿色背景的等亮度蓝红点。结果显示，精神分裂症患者及其兄弟姐妹在M通路条件下的损害比在P途径条件下更严重。没有颜色相关的损害。与对照组相比，患者和他们的兄弟姐妹在执行功能、精神运动速度和言语记忆方面的测试表现较差。视觉-知觉和神经心理学数据没有相关性。结论：M通路功能障碍是精神分裂症的一种潜在的内表型。
Visual information processing is impaired in schizophrenia patients and their biological relatives. The authors measured vernier thresholds in 72 schizophrenia patients, their 86 siblings, and 60 healthy control subjects. Subjects were asked to detect the direction of the horizontal displacement of 2 stimuli (left or right). During magnocellular (M) pathway tests, stimuli were dots with low contrast (5%) or counterphase-modulated gratings (25 Hz). For parvocellular (P) pathway tests, isoluminant blue-red dots with yellow-green background were used. Results revealed that patients with schizophrenia and their siblings were more impaired in M pathway conditions than in P pathway conditions. There was no color-specific impairment. The patients and their siblings displayed lower performances on tests of executive functions, psychomotor speed, and verbal memory compared with the controls. Visual-perceptual and neuropsychological data did not correlate. In conclusion, M pathway dysfunction is a potential endophenotype of schizophrenia.