Serum tau levels are increased in patients with hyperthyroidism
Serum tau levels are increased in patients with hyperthyroidism
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甲状腺功能亢进症患者血清 tau 水平升高
DOI：
10.1016/j.neulet.2020.135003
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发表时间：
2020-06-11
影响因子：
2.5
通讯作者：
Zhang, Li-Li
中科院分区：
文献类型：
--
作者：
Li, Lun-Xi;Yang, Tong;Zhang, Li-Li
甲状腺功能亢进症可能会导致认知能力下降，并增加阿尔茨海默病（AD）的风险，阿尔茨海默病是痴呆的主要形式;然而，这种关系的潜在机制尚不清楚。AD与血清tau水平升高相关。在这项研究中，我们调查了血清甲状腺激素（TH）和tau蛋白之间的关系。50名被诊断为甲状腺功能亢进症的参与者和50名甲状腺功能正常的参与者被纳入并接受临床检查。测定血清促甲状腺激素（TSH）、游离甲状腺素（FT 4）、游离三碘甲状腺原氨酸（FT 3）和tau蛋白浓度。甲状腺功能亢进患者的总tau蛋白水平显著高于甲状腺功能正常者。循环总tau水平与血清FT 3和FT 4浓度呈显著正相关。低TSH组总tau水平随年龄增长而升高，血清TH水平随年龄增长而降低。这些结果表明，外周TH与血清tau浓度相关，其可能参与AD的发病机制，提示通过甲亢治疗AD的潜在治疗靶点。
Hyperthyroidism may cause cognitive decline and increases the risk of Alzheimer's disease (AD), the major form of dementia; however, the underlying mechanism of this relationship is unclear. AD is associated with increased serum levels of tau. In this study, we investigated the relationship between serum thyroid hormones (THs) and tau. Fifty participants diagnosed with hyperthyroidism and fifty euthyroid counterparts were included and received clinical examinations. Serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and tau protein were assessed. The total tau protein level was significantly higher in hyperthyroidism participants than in their euthyroid counterparts. The level of circulating total tau had a significant positive association with the serum concentrations of FT3 and FT4. Total tau level was increased in the low TSH group and the serum THs decreased with the increase of age. These findings reveal that peripheral THs are associated with the serum concentration of tau, which may be involved in the pathogenesis of AD, suggesting a potential therapeutic target of AD via hyperthyroidism therapy.