Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats
Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats
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DOI：
10.1007/s00213-008-1174-z
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发表时间：
2008-09-01
影响因子：
3.4
通讯作者：
Salamone, John D.
中科院分区：
文献类型：
--
作者：
Font, Laura;Mingote, Susana;Salamone, John D.
多巴胺（DA）参与工具性行为的调节，包括行为激活和努力相关的选择行为。多巴胺传递受损的大鼠将其行为从具有高反应要求的食物强化活动中重新分配，而是选择不太费力的寻食行为。虽然多巴胺被认为是大脑回路调节努力相关过程的关键组成部分，目的探讨腺苷A（2A）受体激动是否能产生与多巴胺（DA）耗竭或拮抗类似的效应。激动剂CGS 21680对并行选择任务（杠杆按压优选食物与摄入不太优选的食物）的性能的影响，已知所述并行选择任务对DA拮抗剂和多巴胺（DA）耗竭敏感。相比之下，向双侧丘脑底核注入腺苷A（2A）受体激动剂CGS 21680（6.0-24.0 ng）可减少对首选食物的杠杆按压，但显著增加对较不首选食物的消耗。CGS 21680注射到一个控制网站背对的adrenbens.Conclusions总的来说，这些结果是一致的假设，即局部刺激adenosine A（2A）受体在adrenbens产生类似的行为效应所诱导的adrenbens DA耗竭。Accumbens腺苷A（2A）受体似乎是调节与努力相关的选择行为的大脑回路的一个组成部分。
Rationale Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission reallocate their behavior away from food-reinforced activities that have high response requirements and instead select less-effortful types of food-seeking behavior. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A(2A) receptors.Objective The present work was undertaken to test the hypothesis that accumbens A(2A) receptor stimulation would produce effects similar to those produced by DA depletion or antagonism.Materials and methods Three experiments assessed the effects of the adenosine A(2A) agonist CGS 21680 on performance of a concurrent choice task (lever pressing for preferred food vs. intake of less preferred chow) that is known to be sensitive to DA antagonists and accumbens DA depletions.Results Systemic injections of CGS 21680 reduced lever pressing but did not increase feeding. In contrast, bilateral infusions of the adenosine A(2A) receptor agonist CGS 21680 (6.0-24.0 ng) into the nucleus accumbens decreased lever pressing for the preferred food but substantially increased consumption of the less preferred chow. Injections of CGS 21680 into a control site dorsal to the accumbens were ineffective.Conclusions Taken together, these results are consistent with the hypothesis that local stimulation of adenosine A(2A) receptors in nucleus accumbens produces behavioral effects similar to those induced by accumbens DA depletions. Accumbens adenosine A(2A) receptors appear to be a component of the brain circuitry regulating effort-related choice behavior.