Structural modification of acyl carrier protein by butyryl group.
Structural modification of acyl carrier protein by butyryl group.
复制标题
丁酰基对酰基载体蛋白的结构修饰。
DOI：
10.1002/pro.11
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Zheng,JieJ
中科院分区：
文献类型：
--
作者：
Wu,Bai-Nan;Zhang,Yong-Mei;Rock,CharlesO;Zheng,JieJ
Fatty acid synthesis in bacteria is catalyzed by a set of individual enzymes known as the type II fatty acid synthase. Acyl carrier protein (ACP) shuttles the acyl intermediates between individual pathway enzymes. In this study, we determined the solution structures of three different forms of ACP, apo‐ACP, ACP, and butyryl‐ACP under identical experimental conditions. The structural studies revealed that attachment of butyryl acyl intermediate to ACP alters the conformation of ACP. This finding supports the more general notion that the attachment of different acyl intermediates alters the ACP structure to facilitate their recognition and turnover by the appropriate target enzymes.
