Histocompatibility antigens : structure and function
Histocompatibility antigens : structure and function
复制标题
组织相容性抗原：结构和功能
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. Strominger
中科院分区：
文献类型：
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作者：
P. Parham;J. Strominger
主要组织相容性复合体(MHC)是癌症生物学家在本世纪初遇到的一个慢性问题的联合序列：在近交系小鼠中，未能通过连续传代维持肿瘤细胞系。许多观察指出，遗传相似性是成功移植的先决条件，C.C.利特尔将它们纳入了移植的遗传学理论。这促使像利特尔这样的科学家开始进行育种实验，以检验他的假设，并培育出基因相同的小鼠，从而允许移植肿瘤的生长。大多数免疫学常用的近交系小鼠都是从这些努力中衍生出来的。正常组织的移植遵循与恶性组织相同的规则，排斥反应被证明是一种免疫学现象。斯内尔的研究表明，皮肤移植物的快速排斥反应是由单个基因决定的。这最初被称为主要组织亲和性基因座，但后来被证明包括许多功能相关的基因，并更名为主要组织亲和性复合体(MHC)。在小鼠身上，这是H-2复合体，在人类身上，这是人类白细胞抗原复合体。在这段时间里，P.A.
The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A."